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Table 1 Baseline characteristics of nested case-control participants by breast cancer status (n = 236), all other participants in the full unaffected cohort (n = 1729), New York Site of the BCFR

From: Circulating growth factor concentrations and breast cancer risk: a nested case-control study of IGF-1, IGFBP-3, and breast cancer in a family-based cohort

  Cases: women withbreast cancer, N = 80 Matched controls: womenwithout breast cancer, N = 156 Nested case-controltotal, N = 236 Unaffected cohort,N = 1729
  N (%) N (%) N (%) N (%)
Age at blood draw
Mean years (s.d.) 46.2 (10.3) 45.5 (10.9) 45.8 (10.7) 42.8 (13.2)b
Ethnicity
 Non-Hispanic White 71 (88.8) 134 (85.9) 205 (86.9) 1136 (65.7)
 Hispanic 9 (11.3) 20 (12.8) 29 (12.3) 414 (23.9)
 Others 0 (0) 2 (1.3) 2 (0.9) 179 (10.4)
BMI
Mean kg/m2 (s.d.) 24.6 (4.5) 23.8 (4.4) 24.1 (4.4) 25.2 (5.6)
Menopausal status
 Pre-menopausal 52 (65.0) 112 (71.8) 164 (71.9) 1129 (67.0)
 Post-menopausal 27 (33.8) 37 (23.7) 64 (28.1) 557 (33.0)
Smoking status
 Current 6 (7.5) 14 (9.0) 20 (8.5) 153 (8.9)
 Former 29 (36.3) 44 (28.2) 73 (31.1) 513 (29.8)
 Never 44 (55.0) 98 (62.8) 142 (60.4) 1054 (61.3)
Alcohol consumption
 Current 27 (33.8) 58 (37.2) 85 (36.5) 505 (29.4)
 Former 17 (21.3) 24 (15.4) 41 (17.6) 505 (16.7)
 Never 36 (45.0) 71 (45.5) 107 (45.9) 943 (54.9)
BOADICEA score
Mean (s.d.) 7.94 (7.2) 5.55 (5.0) 6.76 (6.84) 4.88 (6.1)
 Average risk (< 3.4%) 19 (23.8) 56 (35.9) 75 (32.5) 841 (48.6)
 Elevated risk (≥ 3.4%) 61 (76.3) 95 (60.9) 156 (67.5) 888 (51.4)
IGF-1 level (ng/mL)
Geometric mean (geometric s.d.) 95.0 (1.46) 93.9 (1.45) 94.3 (1.45) N/A
Median (IQR) 99.6 (45.6) 94.0 (45.8) 96.4 (45.9) N/A
 < 93.95 34 (42.5) 78 (50.0) 112 (47.5) N/A
 Elevated (≥ 93.95)a 46 (57.5) 78 (50.0) 124 (52.5) N/A
IGFBP-3 level (ng/mL)  
Geometric mean (geometric s.d.) 2069.3 (1.25) 1960.3 (1.32) 1996.6 (1.30) N/A
Median (IQR) 2097 (635) 2009 (652) 2057 (638) N/A
 < 2009 34 (42.5) 78 (50.0) 112 (47.5) N/A
 Elevated (≥ 2009)a 46 (57.5) 78 (50.0) 124 (52.5) N/A
  1. Abbreviations: BCFR Breast Cancer Family Registry, BMI body mass index, BOADICEA Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm, IGF-1 insulin-like growth factor 1, IGFBP-3 insulin-like growth factor binding protein 3, IQR interquartile range
  2. aBiomarker elevation defined as greater than or equal to the median value in controls
  3. bAge at interview (blood draw N/A)