Fig. 4

KYNU enzyme expression and activity in HC and various BrCa subtypes. a KYNU mRNA expression level is most significantly increased in HER2-enriched BrCa patient tumor tissues from the METABRIC dataset. b KYNU protein immunohistochemistry in BrCa tissues shows that KYNU expression is highest in the TN BrCa subtype. Representative images of KYNU staining in BrCa tumor tissue subtypes are shown with semi-quantification (n = 10 each subtype; scale bar, 1000 μM)