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Table 1 Baseline tumor and patient characteristics in relation to CYP27A1 expression

From: CYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients

  MDCS BC-blood
CYP27A1 low CYP27A1 high OR *(95% CI) CYP27A1 low CYP27A1 high OR* (95% CI)
Characteristic N (%) N (%)   N (%) N (%)  
510 (79.1) 135 (20.9)   588 (72.3) 225 (27.7)  
Age at BC diagnosis 64.9 (60.1–71.1)a 66.2 (60.4–73.5)a 1.02 (0.99–1.05) 60.7 (52.4–67.8)a 61.3 (52.3–69.2)a 1.00 (0.98–1.01)
 Age at diagnosis < 55 yrs 53 (10) 10 (7.4) ref 179 (30.4) 74 (32.9) ref
 Age at diagnosis ≥ 55 yrs 457 (90) 125 (92.6) 0.94 (0.44–2.00) 409 (69.6) 151 (67.1) 0.84 (0.60–1.18)
Estrogen receptor status
 Positive 428 (89.7) 94 (78.3) ref 545 (92.7) 166 (74.1) ref
 Negative 49 (10.3) 26 (12.6) 2.52 (1.50–4.20) 43 (7.3) 58 (25.9) 4.75 (3.05–7.41)
Progesterone receptor status
 Positive 243 (56.4) 52 (47.3) ref 445 (75.7) 135 (60.3) ref
 Negative 188 (43.6) 58 (52.7) 1.81 (1.16–2.84) 143 (24.3) 89 (39.7) 2.17 (1.55–3.03)
Tumor size
 ≤ 20 mm 353 (69.6) 92 (68.1) ref 446 (75.9) 150 (66.7) ref
 > 20 mm 154 (30.4) 43 (31.9) 1.10 (0.73–1.70) 142 (24.1) 75 (33.3) 1.62 (1.15–2.27)
Nodal status
 Negative 304 (63.3) 90 (68.7) ref 351 (59.8) 144 (64.3) ref
 Positive 176 (36.7) 41 (31.3) 0.81 (0.54–1.23) 236 (40.2) 80 (35.7) 0.84 (0.61–1.16)
Nottingham histological grade
 I and II 369 (73.9) 82 (62.6) ref 466 (79.3) 134 (59.6) ref
 III 130 (26.1) 49 (37.4) 1.70 (1.13–2.60) 122 (20.7) 91 (40.4) 2.37 (1.69–3.32)
FFPE block storage time, yrs 15.0 (12.0–19.0)a 13.0 (10.0–17.0)a 0.93 (0.89–0.97) 10.0 (7.0–12.0)a 8.0 (6.0–11.0)a 0.87 (0.82–0.92)
Radiotherapy
 No 160 (34.3) 55 (44.4) ref 214 (36.4) 78 (34.7) ref
 Yes 307 (65.7) 69 (55.6) 0.65 (0.43–0.97) 374 (63.6) 147 (65.3) 1.06 (0.76–1.47)
Endocrine therapy
 No 204 (40.6) 50 (37.9) ref 158 (26.9) 84 (37.3) ref
 Yes 298 (59.4) 82 (62.1) 0.93 (0.61–1.40) 429 (73.1) 140 (62.5) 0.62 (0.45–0.87)
Chemotherapy
 No 388 (82.9) 97 (78.9) ref 457 (77.7) 149 (66.2) ref
 Yes 80 (17.1) 26 (21.1) 1.23 (0.74–2.03) 131 (22.3) 76 (33.8) 1.51 (1.07–2.14)
  1. aMedian (IQR), OR odds ratio, ref reference category, FFPE formalin-fixed paraffin-embedded, yrs years. Bold numbers indicate statistically significant comparisons
  2. *Odds ratios are only adjusted for storage time of FFPE blocks