Association between indicators of systemic inflammation biomarkers during puberty with breast density and onset of menarche

Table 4 Association between inflammatory marker measurement at Tanner 2 and Tanner 4 with relative time to menarche

Inflammatory marker	Breast Tanner stage	N	Events^D	Relative time to menarche per doubling of inflammatory marker; time ratio (95% CI)
Age-adjusted model^A
CRP	Tanner 2	348	302	1.00 (0.99–1.00)
CRP	Tanner 4	298	291	1.01 (1.00–1.01)***
IL-6	Tanner 2	381	335	0.99 (0.99–1.00)*
IL-6	Tanner 4	298	291	1.00 (1.00–1.01)
TNFR2	Tanner 2	381	335	0.97 (0.95–0.99)*
TNFR2	Tanner 4	298	291	1.00 (0.98–1.02)
Age and body fatness-adjusted model^B
CRP	Tanner 2	347	301	1.00 (0.99–1.00)
CRP	Tanner 4	298	291	1.01 (1.00–1.01)***
IL-6	Tanner 2	380	334	0.99 (0.99–1.00)*
IL-6	Tanner 4	298	291	1.00 (0.99–1.01)
TNFR2	Tanner 2	380	334	0.97 (0.95–1.00)*
TNFR2	Tanner 4	298	291	1.00 (0.98–1.01)
Multivariable-adjusted model^C
CRP	Tanner 2	336	291	1.00 (0.99–1.00)
CRP	Tanner 4	291	284	1.01 (1.00–1.01)***
IL-6	Tanner 2	369	324	0.99 (0.98–1.00)**
IL-6	Tanner 4	291	284	1.00 (0.99–1.01)
TNFR2	Tanner 2	369	324	0.98 (0.96–1.00)*
TNFR2	Tanner 4	291	284	1.00 (0.98–1.02)

^AAccelerated failure time model for time to menarche from birth adjusting for age at inflammatory biomarker measurement
^BModel adjusting for age at inflammatory biomarker measurement and fat percentage at biomarker measurement
^CModel adjusting for age at inflammatory biomarker measurement, fat percentage at biomarker measurement, ethnicity, birth weight, height age- and sex-specific Z-score, and maternal education
^DNumber of girls reaching menarche during follow-up period
*p < 0.05
**p < 0.01
***p < 0.001

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