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Table 2 Percentage change in FES uptake from baseline to day 14 for the two different dose cohorts

From: A phase 1b study evaluating the effect of elacestrant treatment on estrogen receptor availability and estradiol binding to the estrogen receptor in metastatic breast cancer lesions using 18F-FES PET/CT imaging

 

Elacestrant dose cohort

Parameter

200/400 mg (N = 8)

400 mg (N = 8)

Overall (N = 16)

Number evaluated, n (%)

8 (100)a

8 (100)

16 (100)

Mean (SD), %

− 82.6 (15.5)

− 86.0 (10.2)

− 84.3 (12.8)

Median (Q1, Q3), %

− 89.1 (− 94.2, − 67.6)

− 88.7 (− 94.1, − 79.5)

− 89.1 (− 94.1, − 75.1)

  1. ITT intention to treat, FES 16α-18F-fluoro-17β-estradiol
  2. aOne patient who had < − 100% change (i.e., > 100% reduction) was included as − 100%