Pubertal timing and breast cancer risk in the Sister Study cohort

Goldberg, Mandy; D’Aloisio, Aimee A.; O’Brien, Katie M.; Zhao, Shanshan; Sandler, Dale P.

doi:10.1186/s13058-020-01326-2

Breast Cancer Research

Table 2 Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between pubertal timing and tempo and incident breast cancer in the Sister Study cohort

From: Pubertal timing and breast cancer risk in the Sister Study cohort

	Person-years	N cases	Minimally adjusted^a		Fully adjusted^b		Mutually adjusted^c
	Person-years	N cases	HR	95% CI	HR	95% CI	HR	95% CI
Age at pubertal milestone
Age at thelarche
< 10 years	15,806	135	1.22	1.03, 1.46	1.23	1.03, 1.46	1.15	0.95, 1.39
10–11 years	125,803	921	1.02	0.95, 1.11	1.03	0.95, 1.11	0.98	0.90, 1.08
12–13 years	238,712	1725	1.00	Referent	1.00	Referent	1.00	Referent
> 13 years	79,405	514	0.91	0.82, 1.00	0.91	0.82, 1.00	0.93	0.84, 1.04
Continuous (per 1-year later)	459,726	3295	0.97	0.95, 0.99	0.97	0.95, 0.99	0.99	0.96, 1.02
Age at menarche
< 12 years	93,485	742	1.10	1.01, 1.20	1.10	1.01, 1.20	1.09	0.99, 1.20
12–13 years	258,756	1849	1.00	Referent	1.00	Referent	1.00	Referent
> 13 years	107,484	704	0.92	0.84, 1.00	0.92	0.85, 1.01	0.95	0.86, 1.04
Continuous (per 1-year later)	459,726	3295	0.96	0.94, 0.98	0.96	0.94, 0.98	0.97	0.94, 1.00
Age reached adult height
< 15 years	116,762	878	0.97	0.89, 1.06	0.97	0.89, 1.06	0.94	0.86, 1.03
15–17 years	188,674	1412	1.00	Referent	1.00	Referent	1.00	Referent
> 17 years	154,289	1005	0.87	0.80, 0.94	0.87	0.80, 0.95	0.88	0.81, 0.95
Continuous (per 1-year later)	459,726	3295	0.99	0.97, 1.00	0.99	0.97, 1.00	0.99	0.98, 1.01
Pubertal tempo
Time from thelarche to menarche
< 0 years	81,423	592	1.01	0.92, 1.11	1.01	0.92, 1.11	1.06	0.95, 1.17
0 years	169,355	1239	1.00	Referent	1.00	Referent	1.00	Referent
1 year	130,298	913	0.97	0.89, 1.05	0.96	0.89, 1.05	0.95	0.87, 1.03
> 1 year	78,650	551	0.99	0.90, 1.10	1.00	0.90, 1.10	0.96	0.86, 1.06
Continuous (per 1-year longer)	459,726	3295	0.99	0.97, 1.02	0.99	0.97, 1.02	0.97	0.94, 1.00
Time from menarche to adult height
< 2 years	95,450	702	0.98	0.89, 1.08	0.98	0.89, 1.08	0.99	0.90, 1.09
2–3 years	137,145	973	0.97	0.89, 1.06	0.97	0.89, 1.06	0.98	0.89, 1.07
4–5 years	134,086	971	1.00	Referent	1.00	Referent	1.00	Referent
> 5 years	93,045	649	0.96	0.87, 1.06	0.96	0.87, 1.06	0.93	0.84, 1.03
Continuous (per 1-year longer)	459,726	3295	1.00	0.99, 1.02	1.00	0.99, 1.02	0.99	0.98, 1.01

N = 49,686 women included in each model. No violations of proportional hazards assumption for any of the exposures of interest
^aAdjusted for attained age as the underlying time scale and stratified by birth cohort
^bAdditionally adjusted for race/ethnicity and family income level growing up
^cFully adjusted model with mutual adjustment for ages at thelarche and menarche. Age reached adult height is adjusted for age at menarche. Pubertal tempo models are adjusted for age at thelarche (for the thelarche-menarche model) and age at menarche (for the menarche-height model)

Back to article page

ISSN: 1465-542X

Contact us

Submission enquiries: journalsubmissions@springernature.com