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Table 2 Hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between pubertal timing and tempo and incident breast cancer in the Sister Study cohort

From: Pubertal timing and breast cancer risk in the Sister Study cohort

  Person-years N cases Minimally adjusteda Fully adjustedb Mutually adjustedc
HR 95% CI HR 95% CI HR 95% CI
Age at pubertal milestone
 Age at thelarche
 < 10 years 15,806 135 1.22 1.03, 1.46 1.23 1.03, 1.46 1.15 0.95, 1.39
 10–11 years 125,803 921 1.02 0.95, 1.11 1.03 0.95, 1.11 0.98 0.90, 1.08
 12–13 years 238,712 1725 1.00 Referent 1.00 Referent 1.00 Referent
 > 13 years 79,405 514 0.91 0.82, 1.00 0.91 0.82, 1.00 0.93 0.84, 1.04
 Continuous (per 1-year later) 459,726 3295 0.97 0.95, 0.99 0.97 0.95, 0.99 0.99 0.96, 1.02
 Age at menarche
 < 12 years 93,485 742 1.10 1.01, 1.20 1.10 1.01, 1.20 1.09 0.99, 1.20
 12–13 years 258,756 1849 1.00 Referent 1.00 Referent 1.00 Referent
 > 13 years 107,484 704 0.92 0.84, 1.00 0.92 0.85, 1.01 0.95 0.86, 1.04
 Continuous (per 1-year later) 459,726 3295 0.96 0.94, 0.98 0.96 0.94, 0.98 0.97 0.94, 1.00
 Age reached adult height
 < 15 years 116,762 878 0.97 0.89, 1.06 0.97 0.89, 1.06 0.94 0.86, 1.03
 15–17 years 188,674 1412 1.00 Referent 1.00 Referent 1.00 Referent
 > 17 years 154,289 1005 0.87 0.80, 0.94 0.87 0.80, 0.95 0.88 0.81, 0.95
 Continuous (per 1-year later) 459,726 3295 0.99 0.97, 1.00 0.99 0.97, 1.00 0.99 0.98, 1.01
Pubertal tempo
 Time from thelarche to menarche
 < 0 years 81,423 592 1.01 0.92, 1.11 1.01 0.92, 1.11 1.06 0.95, 1.17
 0 years 169,355 1239 1.00 Referent 1.00 Referent 1.00 Referent
 1 year 130,298 913 0.97 0.89, 1.05 0.96 0.89, 1.05 0.95 0.87, 1.03
 > 1 year 78,650 551 0.99 0.90, 1.10 1.00 0.90, 1.10 0.96 0.86, 1.06
 Continuous (per 1-year longer) 459,726 3295 0.99 0.97, 1.02 0.99 0.97, 1.02 0.97 0.94, 1.00
 Time from menarche to adult height
 < 2 years 95,450 702 0.98 0.89, 1.08 0.98 0.89, 1.08 0.99 0.90, 1.09
 2–3 years 137,145 973 0.97 0.89, 1.06 0.97 0.89, 1.06 0.98 0.89, 1.07
 4–5 years 134,086 971 1.00 Referent 1.00 Referent 1.00 Referent
 > 5 years 93,045 649 0.96 0.87, 1.06 0.96 0.87, 1.06 0.93 0.84, 1.03
 Continuous (per 1-year longer) 459,726 3295 1.00 0.99, 1.02 1.00 0.99, 1.02 0.99 0.98, 1.01
  1. N = 49,686 women included in each model. No violations of proportional hazards assumption for any of the exposures of interest
  2. aAdjusted for attained age as the underlying time scale and stratified by birth cohort
  3. bAdditionally adjusted for race/ethnicity and family income level growing up
  4. cFully adjusted model with mutual adjustment for ages at thelarche and menarche. Age reached adult height is adjusted for age at menarche. Pubertal tempo models are adjusted for age at thelarche (for the thelarche-menarche model) and age at menarche (for the menarche-height model)