Fig. 3

Normal breast adipocyte size and gene expression signatures in relation to Active and Inactive transcriptome phenotypes. a Representative H&E image (sample K102670) showing automated adipocyte delineation for cross-sectional area determination on each sample, and distribution plots of mean adipocyte areas for all 151 samples according to their donor’s BMI (r = 0.48, p < 0.0001) and the sample’s transcriptome phenotype as either Active or Inactive (**p < 0.01). b Batch-specific (F, P) box plot distributions of a previously reported breast cancer-associated cAMP-dependent lipolysis signature [8, 12] according to sample transcriptome phenotype assignment (expression cluster) as either Active or Inactive. c Batch-specific (F, P) box plot distributions of a previously reported breast cancer-associated white adipocyte browning signature [13] shown according to sample transcriptome phenotype assignment (expression cluster) as either Active or Inactive