Table 6 Breast cancer odds ratio (ORs) in relation to participant’s in utero exposures by ER status, with counts including only participants with complete information on exposure of interest
From: Perinatal and postnatal exposures and risk of young-onset breast cancer
Characteristics | ER+ cases (1161 case subjects, 1321 control subjects) | ER− cases (290 case subjects, 328 control subjects) | ||||||
|---|---|---|---|---|---|---|---|---|
Controls (n = 1321) | Cases (n = 1161) | OR (95% CI) | OR (95% CI) | Controls (n = 328) | Cases (n = 290) | OR (95% CI) | OR (95% CI) | |
Preeclampsia/eclampsia/toxemia | ||||||||
No | 949 (98.3) | 840 (98.4) | 1.00 | 1.00 | 200 (98.5) | 174 (95.6) | 1.00 | 1.00 |
Yes | 16 (1.7) | 14 (1.6) | 1.23 (0.48–3.16)¥ | 1.41 (0.50–3.97)€ | 3 (1.5) | 8 (4.4) | ǂ | ǂ |
Gestational hypertension§ | ||||||||
No | 913 (97.5) | 794 (98.0) | 1.00 | 1.00 | 196 (97.5) | 161 (97.0) | 1.00 | 1.00 |
Yes | 23 (2.5) | 16 (2.0) | 0.75 (0.35–1.60)¥ | 0.87 (0.38–1.97)€ | 5 (2.5) | 5 (3.0) | 1.09 (0.31–3.79)¥ | 1.37 (0.36–5.19)€ |
Any hypertensive disorder | ||||||||
No | 944 (96.0) | 843 (95.6) | 1.00 | 1.00 | 200 (96.2) | 173 (93.0) | 1.00 | 1.00 |
Yes | 39 (4.0) | 30 (3.4) | 0.86 (0.46–1.59)¥ | 0.98 (0.50–1.90)€ | 8 (3.9) | 13 (7.0) | 2.83 (0.85–9.39)¥ | 5.61 (1.19–26.4)€ |
Maternal smoking | ||||||||
No | 757 (70.4) | 665 (70.0) | 1.00 | 166 (71.9) | 145 (70.0) | 1.00 | ||
Yes | 319 (29.6) | 285 (30.0) | 1.18 (0.77–1.82)* | 65 (28.1) | 62 (30.0) | 1.23 (0.54–2.80)* | ||
Low birth weight | ||||||||
Birth weight > 5.5 pounds | 992 (93.5) | 867 (92.3) | 1.00 | 1.00 | 218 (91.9) | 199 (91.7) | 1.00 | 1.00 |
Birth weight ≤ 5.5 pounds | 69 (6.5) | 72 (7.7) | 1.23 (0.82–1.85) | 1.22 (0.76–1.96)Ŧ | 19 (8.0) | 18 (8.3) | 0.95 (0.46–1.98) | 0.85 (0.35–2.05)Ŧ |
High birth weight | ||||||||
Birth weight < 8.8 pounds | 712 (92.6) | 614 (90.2) | 1.00 | 1.00 | 162 (92.1) | 150 (91.5) | 1.00 | 1.00 |
Birth weight ≥ 8.8 pounds | 57 (7.4) | 67 (9.8) | 1.68 (1.07–2.62) | 1.53 (0.95–2.48)Ŧ | 14 (7.9) | 14 (8.5) | 1.34 (0.55–3.28) | 1.35 (0.48–3.80)Ŧ |
Breastfed | ||||||||
No | 640 (60.2) | 582 (61.8) | 1.00 | 130 (57.5) | 134 (65.7) | 1.00 | ||
Yes | 424 (39.9) | 360 (38.2) | 0.83 (0.61–1.13) | 96 (42.5) | 70 (34.3) | 0.53 (0.29–0.99) | ||
Soy-fed (formula made from soy) | ||||||||
No | 827 (96.3) | 722 (95.5) | 1.00 | 181 (94.3) | 163 (95.3) | 1.00 | ||
Yes | 32 (3.7) | 34 (4.5) | 1.19 (0.70–2.01) | 11 (5.7) | 8 (4.7) | 0.70 (0.27–1.84) | ||
DES exposure during pregnancy | ||||||||
No | 860 (96.9) | 770 (97.2) | 1.00 | 171 (98.3) | 152 (98.1) | 1.00 | ||
Yes | 28 (3.2) | 22 (2.8) | 0.85 (0.44–1.65) | 3 (1.7) | 3 (1.9) | 1.00 (0.14–7.10) | ||
Short gestational length at birth | ||||||||
Born ≥ 38 weeks | 460 (87.3) | 400 (84.8) | 1.00 | 1.00 | 93 (91.2) | 82 (85.4) | 1.00 | 1.00 |
Born < 38 weeks | 67 (12.7) | 72 (15.2) | 1.25 (0.82–1.92) | 1.19 (0.76–1.85)Ŧ | 9 (8.8) | 14 (48.6) | 2.39 (0.73–7.79) | 2.11 (0.52–8.59)Ŧ |