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Fig. 7 | Breast Cancer Research

Fig. 7

From: Secreted breast tumor interstitial fluid microRNAs and their target genes are associated with triple-negative breast cancer, tumor grade, and immune infiltration

Fig. 7

Oncogenes and tumor suppressors in co-expression modules. Tile plots depicting how many genes within five selected modules had been annotated as either an oncogene (orange), a tumor suppressor (green), a dual role/mixed role (purple), or a driver/fusion gene (yellow). The plots contain all genes from modules which were annotated in COSMIC [75] or which met the cutoff for a CancerMine hit [76], as well as all differentially expressed genes and all genes from miRNA-mRNA interaction networks. a Green module. b Yellow module. c Red module. d Light cyan module. e Sky blue module. f Blue module. The large number of dual role genes from CancerMine observed in the plots, arise from the fact that these genes are not curated, and as such have a variety of roles annotated within and between cancers. Additional file 14, Table S6 contains the number of cancer-related genes within each of the 28 modules (3 modules had no genes with annotation)

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Breast Cancer Research

ISSN: 1465-542X

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