Fig. 5

Co-abundant miRNA-mRNA pairs. Dot plots showing the differentially co-expressed genes and their predicted co-abundant miRNA regulators, for the green, yellow, and red modules. Colors: light orange = TIF miRNA upregulated in given comparison, dark blue = TIF miRNA downregulated in given comparison; N. B genes have the inverse direction of expression as miRNAs. Bar plots relay information about genes extracted from the COSMIC database [75]. Height/shade of the bar indicates gene rank, based on the mutational burden (SNPs classified as pathogenic) and copy number variations (CNVs, grain + loss) of a gene from breast tumors. Colors of the bars denote if the gene was classified as a BC oncogene, a BC driver gene, a BC tumor suppressor gene, or a BC dual role gene within the set of COSMIC gene census set [75] and/or from CancerMine [76]. A star means that a gene was annotated in COSMIC or CancerMine for another cancer than BC, and the color indicates the gene role. Smaller dots adjacent to miRNA name denote miRNA co-abundance modules (modules 1–3). Shades: black = module 1, green = module 2, and gray = module 3