Skip to main content

Table 1 Patient and tumour characteristics of the study population

From: Tumour-infiltrating lymphocytes and response to neoadjuvant letrozole in patients with early oestrogen receptor-positive breast cancer: analysis from a nationwide phase II DBCG trial

 

All patients, n = 106

Patients with low TILs, n = 81

Patients with intermediate TILs, n = 25

 

Characteristic

n

% (col)

n

% (col)

n

% (col)

p1

Age (years)

0.12

 60–69

44

(41)

44

(54)

18

(72)

 

 70–89

62

(59)

37

(46)

7

(28)

 

Tumour size (mm)2

0.32

 <  20

46

(43)

33

(41)

13

(52)

 

 ≥ 20

60

(57)

48

(59)

12

(48)

 

Histological subtype

0.40

 Ductal

76

(72)

56

(70)

19

(76)

 

 Lobular

12

(11)

11

(14)

1

(4)

 

 Other invasive3

17

(16)

13

(16)

5

(20)

 

 Unknown

1

(1)

1

(1)

0

  

Malignancy grade4

0.96

 1

37

(43)

28

(42)

9

(45)

 

 2

45

(52)

35

(52)

10

(50)

 

 3

5

(6)

4

(6)

1

(5)

 

Axillary node status

0.08

 Negative

58

(55)

41

(51)

17

(68)

 

 Positive

47

(44)

40

(49)

7

(28)

 

 Unknown

1

(1)

0

 

1

(4)

 

Oestrogen receptor status (%)

0.18

 10–99

20

(19)

13

(16)

7

(28)

 

 100

86

(81)

68

(84)

18

(72)

 

Progesterone receptor status (%)

0.20

 10–99

75

(71)

57

(70)

18

(72)

 

 100

29

(27)

22

(27)

7

(28)

 

 Unknown

2

(2)

2

(3)

0

(0)

 

Ki67 index (%)

0.02

 < 14

72

(68)

60

(74)

12

(48)

 

 ≥ 14

32

(30)

20

(25)

12

(48)

 

 Unknown

2

(2)

1

(1)

1

(4)

 
  1. 1Excluding unknowns; 2range 11–100 mm; 3other invasive: mucinous carcinomas n = 8, tubular carcinomas n = 2, medullary carcinoma n = 1, not specified n = 6; 4only lobular and ductal tumours graded, n = 88
  2. TILs, tumour-infiltrating lymphocytes