Table 1 The 20 most frequent PIK3CA mutations in BC
From: Frequency and spectrum of PIK3CA somatic mutations in breast cancer
Type of PIK3CA mutation | Exon | Oncogenic by OncoKB24 | Level of evidence to predict alpelisib benefit | Detected by therascreen | Number of mutations found in the combined dataset | Mutation frequency (%) |
|---|---|---|---|---|---|---|
H1047R | 20 | Yes | 1 | Yes | 895 | 35.0 |
E545K | 9 | Yes | 1 | Yes | 447 | 17.5 |
E542K | 9 | Yes | 1 | Yes | 274 | 10.7 |
N345K | 4 | Yes | Yes (preclinical only) | No | 142 | 5.5 |
H1047L | 20 | Yes | 1 | Yes | 103 | 4.0 |
E726K | 13 | Inconclusive. Probably oncogenic | Unknown | No | 65 | 2.5 |
C420R | 7 | Yes | 1 | Yes | 48 | 1.9 |
Q546R | 9 | Yes | 1 | Yes | 27 | 1.1 |
G118D | 1 | Yes | Unknown | No | 26 | 1.0 |
E453K | 7 | Yes | Unknown | No | 22 | 0.9 |
Q546K | 1 | Yes | Yes (preclinical only) | No | 21 | 0.8 |
G1049R | 20 | Yes | Yes (preclinical only) | No | 19 | 0.7 |
M1043I | 20 | Yes | Unknown | No | 19 | 0.7 |
K111E | 1 | Yes | Unknown | No | 16 | 0.6 |
E81K | 1 | Inconclusive. Probably oncogenic | Unknown | No | 15 | 0.6 |
E545A | 9 | Yes | 1 | Yes | 13 | 0.5 |
E545G | 9 | Yes | 1 | Yes | 13 | 0.5 |
N1044K | 20 | Yes | Unknown | No | 12 | 0.5 |
E110del | 1 | Yes | Unknown | No | 11 | 0.4 |
Q546P | 9 | Yes | Unknown | No | 10 | 0.4 |