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Table 1 The 20 most frequent PIK3CA mutations in BC

From: Frequency and spectrum of PIK3CA somatic mutations in breast cancer

Type of PIK3CA mutationExonOncogenic by OncoKB24Level of evidence to predict alpelisib benefitDetected by therascreenNumber of mutations found in the combined datasetMutation frequency (%)
H1047R20Yes1Yes89535.0
E545K9Yes1Yes44717.5
E542K9Yes1Yes27410.7
N345K4YesYes (preclinical only)No1425.5
H1047L20Yes1Yes1034.0
E726K13Inconclusive.
Probably oncogenic
UnknownNo652.5
C420R7Yes1Yes481.9
Q546R9Yes1Yes271.1
G118D1YesUnknownNo261.0
E453K7YesUnknownNo220.9
Q546K1YesYes (preclinical only)No210.8
G1049R20YesYes (preclinical only)No190.7
M1043I20YesUnknownNo190.7
K111E1YesUnknownNo160.6
E81K1Inconclusive.
Probably oncogenic
UnknownNo150.6
E545A9Yes1Yes130.5
E545G9Yes1Yes130.5
N1044K20YesUnknownNo120.5
E110del1YesUnknownNo110.4
Q546P9YesUnknownNo100.4