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Table 3 Best radiological response per protocol arm

From: TBCRC 002: a phase II, randomized, open-label trial of preoperative letrozole with or without bevacizumab in postmenopausal women with newly diagnosed stage 2/3 hormone receptor-positive and HER2-negative breast cancer

Best radiological responses

Letrozole, n = 25

Letrozole/bevacizumab, n = 49

n (%)

95% CI†

n (%)

95% CI†

Complete response (%) (no evidence of residual tumor)

1 (4)

0.1%, 20.4%

5 (10)

3.4%, 22.2%

Partial response

16 (64)

42.5%, 82.0%

34 (69)

54.6%, 81.7%

Objective response rate

17 (68)

46.5%, 85.1%

39 (79)

65.7%, 89.8%

Stable disease

7 (28)

12.1%, 49.4%

10 (21)

10.2%, 34.3%

Progressive disease

1 (4)

0.1%, 20.4%

0 (0)

0, 7.3%

Mean tumor maximum diameter change

− 39%

− 26.4, − 52.2

− 51%

− 43.5, − 58.6

  1. †Exact (Clopper-Pearson) confidence interval