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Table 3 Incidence rates (IRs, per 1000 person-months) and incidence rate ratios (IRRs) of individual psychiatric disorders and cardiovascular diseases during the 6 weeks before diagnosis of women that had a breast diagnostic workup, a population-based cohort study during 2005–2014 in Skåne, Sweden

From: Psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer: a population-based cohort study in Skåne, Sweden

 

Reference group*

Unspecified lump in breast

Benign tumor

Breast cancer

No.

Crude IR

IRR (95% CI)

No.

Crude IR

IRR (95% CI)

No.

Crude IR

IRR (95% CI)

No.

Crude IR

IRR (95% CI)

Psychiatric disorder

 Stress reaction or adjustment disorder

148,638

2.7

1.0

102

4.7

1.2 (1.0–1.5)

32

5.2

1.6 (1.1–2.3)

38

3.3

1.5 (1.1–2.0)

 Depression

296,613

5.5

1.0

165

7.5

1.1 (0.9–1.2)

47

7.6

1.2 (0.9–1.7)

91

7.9

1.3 (1.1–1.6)

 Anxiety

198,330

3.6

1.0

147

6.7

1.3 (1.1–1.6)

31

5.0

1.2 (0.8–1.7)

51

4.4

1.3 (1.0–1.7)

 Substance abuse

58,007

1.1

1.0

31

1.4

1.1 (0.8–1.6)

16

2.6

2.3 (1.4–3.7)

24

2.1

1.8 (1.2–2.7)

 Others

252,763

4.7

1.0

133

6.1

1.0 (0.8–1.2)

29

4.7

0.9 (0.6–1.3)

74

6.4

1.4 (1.1–1.7)

Cardiovascular disease

 Myocardial infarction

18,727

0.3

1.0

3

0.1

0.9 (0.3–2.8)

2

0.3

1.8 (0.4–7.1)

6

0.5

0.8 (0.4–1.9)

 Hypertensive diseases or aneurysm of the heart

525,505

9.7

1.0

130

5.9

0.9 (0.8–1.1)

63

10.2

1.5 (1.1–1.9)

419

36.2

2.1 (2.0–2.4)

 Embolism or thrombosis

13,511

0.2

1.0

3

0.1

0.8 (0.2–2.4)

1

0.2

0.8 (0.1–5.9)

16

1.4

3.4 (2.1–5.5)

 Stroke

33,808

0.6

1.0

3

0.1

0.4 (0.1–1.3)

1

0.2

0.4 (0.1–3.0)

20

1.7

1.5 (1.0–2.4)

 Other diseases of the circulatory system

502,776

9.3

1.0

158

7.2

1.3 (1.1–1.5)

49

8.0

1.2 (0.9–1.6)

316

27.3

1.7 (1.5–1.9)

  1. IR incidence rate, IRR incidence rate ratio
  2. *Reference group included person-time accumulated from women who did not have any breast diagnostic workup during the follow-up and the person-time accumulated before the start of workup from women with a breast diagnostic workup during the follow-up
  3. CI confidence interval. IRRs were estimated using Poisson regression, by using attained age as the underlying timescale and adjusting for cohabitation status, registered parish as a proxy for socioeconomic status, and preexisting psychiatric disorders (for outcome of psychiatric disorders) or preexisting cardiovascular diseases (for outcome of cardiovascular diseases)