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Fig. 8 | Breast Cancer Research

Fig. 8

From: Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells

Fig. 8

In vivo testing of KDOAM25 activity. PLGA or PLGA-KDOAM25 (1 μM, 50 μl volume) were injected into mammary glands once/week for 4 weeks. a Body weights were monitored weekly. b Blood cell levels were determined using the HEMAVET 950FS. c Western blot analyses of indicated proteins in the mammary gland. d Final tumor weights and e upper left panel: lungs from PLGA ± KDOAM25-treated PyMT mice. Upper right panel: quantification of tumor area in hematoxylin and eosin-stained lung tissues. Lower left panel: number of metastatic lesions visible in hematoxylin and eosin-stained lung tissues in the lungs of each mouse. Panels represent 5–6 mice per group (PLGA ± KDOAM25). *P < 0.05 relative to PLGA-treated mice based on t test

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