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Table 2 Unpaired t test of significance for the difference between the two group baseline gene expression means of (i) non-responders vs responders and (ii) noCCCAs vs CCCAs in HER2− group. The means of gene signatures that directly associated with proliferation and represent growth factor signalling pathways were significantly different between AI responder and non-responder tumours, and most of them were statistically different between CCCAs and noCCCAs

From: Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients

Module nameReferenceNon-responders vs respondersnoCCCAs vs CCCAs
Mean (non-responders)Mean (responders)t test p valueFDRMean (no CCCAs)Mean (CCCAs)t test p valueFDR
ERBB2-GS.NoPAGsDesmedt et al.4.9014.7735.01E−033.78E−024.8144.7986.49E−016.49E−01
ERBB2-GSDesmedt et al.4.4754.3485.04E−033.78E−024.3914.3725.98E−016.35E−01
GGI-GS.NoPAGsSotiriou et al.0.6830.5657.83E−033.78E−020.6690.4767.10E−073.02E−06
AURKA-GSDesmedt et al.2.3232.2171.10E−023.78E−022.3112.1394.82E−061.37E−05
IGF1-GSCreighton et al.-0.365− 0.4021.62E−023.78E−02− 0.371− 0.4263.95E−048.39E−04
Immune.2.STAT1.NoPAGsDesmedt et al.7.7207.5261.83E−023.78E−027.6087.5262.27E−013.22E−01
STAT1-GSDesmedt et al.7.8197.6231.84E−023.78E−027.7067.6232.23E−013.22E−01
Gene70-GSvan ‘t Veer et al.3.0292.9282.54E−023.78E−023.0192.8462.19E−067.45E−06
GDNF-GS.NoPAGsMorandi et al.1.5861.4752.61E−023.78E−021.5201.4742.74E−013.58E−01
removedPAGsGao et al.0.5550.5072.65E−023.78E−020.5520.4677.46E−061.81E−05
WntTarget34-GSVerhaeghCR2014TableS18.0918.1912.78E−023.78E−028.1538.1814.70E−015.33E−01
IGF1.NoPAGsCreighton et al.-0.603− 0.6362.91E−023.78E−02− 0.608− 0.6571.09E−032.06E−03
GDNF-GSMorandi et al.1.6991.5913.08E−023.78E−021.6341.5943.31E−014.02E−01
E2Factivation-GS.NoPAGsMiller et al.9.1199.0293.12E−023.78E−029.0918.9967.83E−031.33E−02
JClinInvest2007RBloss-GSBosco et al.7.9617.8023.44E−023.82E−027.9607.6542.83E−071.60E−06
GGI-GSSotiriou et al.5.3645.2193.59E−023.82E−025.3725.0681.55E−071.60E−06
DiLeoRBloss-GSMalorni et al.7.7717.6004.21E−024.21E−027.7817.4232.29E−071.60E−06