Table 2 Unpaired t test of significance for the difference between the two group baseline gene expression means of (i) non-responders vs responders and (ii) noCCCAs vs CCCAs in HER2− group. The means of gene signatures that directly associated with proliferation and represent growth factor signalling pathways were significantly different between AI responder and non-responder tumours, and most of them were statistically different between CCCAs and noCCCAs
Module name | Reference | Non-responders vs responders | noCCCAs vs CCCAs | ||||||
|---|---|---|---|---|---|---|---|---|---|
Mean (non-responders) | Mean (responders) | t test p value | FDR | Mean (no CCCAs) | Mean (CCCAs) | t test p value | FDR | ||
ERBB2-GS.NoPAGs | Desmedt et al. | 4.901 | 4.773 | 5.01E−03 | 3.78E−02 | 4.814 | 4.798 | 6.49E−01 | 6.49E−01 |
ERBB2-GS | Desmedt et al. | 4.475 | 4.348 | 5.04E−03 | 3.78E−02 | 4.391 | 4.372 | 5.98E−01 | 6.35E−01 |
GGI-GS.NoPAGs | Sotiriou et al. | 0.683 | 0.565 | 7.83E−03 | 3.78E−02 | 0.669 | 0.476 | 7.10E−07 | 3.02E−06 |
AURKA-GS | Desmedt et al. | 2.323 | 2.217 | 1.10E−02 | 3.78E−02 | 2.311 | 2.139 | 4.82E−06 | 1.37E−05 |
IGF1-GS | Creighton et al. | -0.365 | − 0.402 | 1.62E−02 | 3.78E−02 | − 0.371 | − 0.426 | 3.95E−04 | 8.39E−04 |
Immune.2.STAT1.NoPAGs | Desmedt et al. | 7.720 | 7.526 | 1.83E−02 | 3.78E−02 | 7.608 | 7.526 | 2.27E−01 | 3.22E−01 |
STAT1-GS | Desmedt et al. | 7.819 | 7.623 | 1.84E−02 | 3.78E−02 | 7.706 | 7.623 | 2.23E−01 | 3.22E−01 |
Gene70-GS | van ‘t Veer et al. | 3.029 | 2.928 | 2.54E−02 | 3.78E−02 | 3.019 | 2.846 | 2.19E−06 | 7.45E−06 |
GDNF-GS.NoPAGs | Morandi et al. | 1.586 | 1.475 | 2.61E−02 | 3.78E−02 | 1.520 | 1.474 | 2.74E−01 | 3.58E−01 |
removedPAGs | Gao et al. | 0.555 | 0.507 | 2.65E−02 | 3.78E−02 | 0.552 | 0.467 | 7.46E−06 | 1.81E−05 |
WntTarget34-GS | VerhaeghCR2014TableS1 | 8.091 | 8.191 | 2.78E−02 | 3.78E−02 | 8.153 | 8.181 | 4.70E−01 | 5.33E−01 |
IGF1.NoPAGs | Creighton et al. | -0.603 | − 0.636 | 2.91E−02 | 3.78E−02 | − 0.608 | − 0.657 | 1.09E−03 | 2.06E−03 |
GDNF-GS | Morandi et al. | 1.699 | 1.591 | 3.08E−02 | 3.78E−02 | 1.634 | 1.594 | 3.31E−01 | 4.02E−01 |
E2Factivation-GS.NoPAGs | Miller et al. | 9.119 | 9.029 | 3.12E−02 | 3.78E−02 | 9.091 | 8.996 | 7.83E−03 | 1.33E−02 |
JClinInvest2007RBloss-GS | Bosco et al. | 7.961 | 7.802 | 3.44E−02 | 3.82E−02 | 7.960 | 7.654 | 2.83E−07 | 1.60E−06 |
GGI-GS | Sotiriou et al. | 5.364 | 5.219 | 3.59E−02 | 3.82E−02 | 5.372 | 5.068 | 1.55E−07 | 1.60E−06 |
DiLeoRBloss-GS | Malorni et al. | 7.771 | 7.600 | 4.21E−02 | 4.21E−02 | 7.781 | 7.423 | 2.29E−07 | 1.60E−06 |