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Table 2 Clinical utility of the 10-year contralateral breast cancer risk prediction model. At the same probability threshold, the net benefit is exemplified in BRCA1/2 mutation carriers (for avoiding unnecessary CPM) and non-carriers (performing necessary CPM)

From: Prediction and clinical utility of a contralateral breast cancer risk model

Probability threshold, pt (%)Unnecessary CPMs needed to prevent one CBC*BRCA1/2 mutation carriersNon-carriers
Net benefit versus treat all patients with CPM (per 1000)Avoided unnecessary CPMs per 1000 patientsNet benefit versus treat none (per 1000)Performed necessary CPMs per 1000 patients
424.00.00.03.993.6
519.00.00.02.139.9
615.70.11.60.57.8
713.31.925.20.11.3
811.55.563.30.00.0
910.110.7108.20.00.0
109.017.9161.10.00.0
  1. CPM contralateral preventive mastectomy, CBC contralateral breast cancer. *The number of unnecessary contralateral mastectomies needed to prevent a CBC is calculated by (1 − pt)/pt. See also Additional file 3: Methods