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Table 2 Clinical utility of the 10-year contralateral breast cancer risk prediction model. At the same probability threshold, the net benefit is exemplified in BRCA1/2 mutation carriers (for avoiding unnecessary CPM) and non-carriers (performing necessary CPM)

From: Prediction and clinical utility of a contralateral breast cancer risk model

Probability threshold, pt (%) Unnecessary CPMs needed to prevent one CBC* BRCA1/2 mutation carriers Non-carriers
Net benefit versus treat all patients with CPM (per 1000) Avoided unnecessary CPMs per 1000 patients Net benefit versus treat none (per 1000) Performed necessary CPMs per 1000 patients
4 24.0 0.0 0.0 3.9 93.6
5 19.0 0.0 0.0 2.1 39.9
6 15.7 0.1 1.6 0.5 7.8
7 13.3 1.9 25.2 0.1 1.3
8 11.5 5.5 63.3 0.0 0.0
9 10.1 10.7 108.2 0.0 0.0
10 9.0 17.9 161.1 0.0 0.0
  1. CPM contralateral preventive mastectomy, CBC contralateral breast cancer. *The number of unnecessary contralateral mastectomies needed to prevent a CBC is calculated by (1 − pt)/pt. See also Additional file 3: Methods