Table 2 Summary of PDX models and metastatic potential. PDX take rate and sites of metastasis following intraductal injection into NOD SCID mice
Model name | Receptor status | Primary tumour growth | Metastasis from primary tumour | Metastases from intra-cardiac injection | ||||
|---|---|---|---|---|---|---|---|---|
Mouse bone | Human bone | Lung | Mouse bone | Human bone | Lung | |||
BB3RC31 | ER+ PR+ HER2− | 100% | 0% | 0% | 60% | NT | NT | NT |
BB3RC32 | ER+ PR+ HER2− | 80% | 75% | 100% | 70% | 80% | 80% | 40% |
BB2RC08 | ER+ PR+ HER2− | 100% | 20% | 100% | 60% | 40% | 80% | 80% |
BB6RC39 | ER+ PR+ HER2+ | 0% | 0% | 0% | 0% | NT | NT | NT |
BB6RC37 | ER− PR− HER2− | 100% | 20% | 20% | 100% | 30% | 30% | 100% |
BB6RC52 | ER− PR− HER2− | 40% | 0% | 0% | 0% | NT | NT | NT |