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Table 2 Risk of subsequent invasive breast cancer overall and by laterality associated with race and ethnicity in women with LCIS

From: Associations of race and ethnicity with risk of developing invasive breast cancer after lobular carcinoma in situ

 Subsequent invasive breast canceraIpsilateral invasive breast cancerbContralateral invasive breast cancerc
Person-yearsCasesHRd (95% CI)Person-yearsCasesHRe (95% CI)Person-yearsCasesHRf (95% CI)
White130,21312641.00120,3347221.00128,9495211.00
Black11,9351421.33 (1.11, 1.59)11,283851.37 (1.08, 1.72)11,818571.33 (1.00, 1.76)
Asian6434550.83 (0.62, 1.10)6137330.87 (0.61, 1.25)6406220.78 (0.49, 1.24)
Hispanic12,2291060.89 (0.72, 1.09)11,564700.99 (0.77, 1.27)12,142360.76 (0.54, 1.08)
  1. Abbreviations: HR hazard ratio, 95% CI 95% confidence interval
  2. aSubsequent invasive breast cancer included invasive breast cancer in either breast and metastatic breast cancer. The analysis included 19,545 women with LCIS
  3. bThe analysis was restricted to 17,843 women who did not have surgical treatment or received breast-conserving surgery for primary LCIS
  4. cThe analysis was restricted to 18,642 women who did not have surgical treatment or received breast-conserving surgery or unilateral mastectomy for primary LCIS
  5. dHRs were adjusted for age (20–39, 40–49, 50–59, 60–69, or ≥ 70 years) and year of the initial LCIS diagnosis (1990–1999, 2000–2009, or 2010–2015), registry, and treatment for primary LCIS (no surgical treatment, breast-conserving surgery alone, breast-conserving surgery followed by radiation therapy, mastectomy, or unknown)
  6. eThe covariates were the same as the above. Treatment was categorized as no surgical treatment, breast-conserving surgery alone, or breast-conserving surgery followed by radiation therapy
  7. fThe covariates were the same as the above. Treatment was categorized as no surgical treatment, breast-conserving surgery alone, breast-conserving surgery followed by radiation therapy, or mastectomy