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Table 2 Adjusted hazard ratios and 95% confidence intervals from Cox proportional hazards modeling of smoking status

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 

Overall BC

ER-positive BC

ER-negative BC

Continuous FRP

Person years

BC

Model 1a

Model 2b

BC

Model 1a

Model 2b

BC

Model 1a

Model 2b

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Never smoker c

102,781.5

559

Reference

Reference

235

Reference

Reference

85

Reference

Reference

 Former smoker

47,088.8

302

1.06 (0.92, 1.22)

1.14 (0.96, 1.34)

118

0.97 (0.77, 1.21)

1.09 (0.84, 1.43)

39

0.95 (0.63, 1.41)

0.92 (0.59, 1.45)

 Current smoker

26,466.7

137

1.02 (0.85, 1.23)

0.92 (0.73, 1.15)

54

1.04 (0.77, 1.40)

1.05 (0.73, 1.51)

27

1.22 (0.78, 1.91)

0.81 (0.46, 1.43)

 Former smoker*FRP

   

0.91 (0.81, 1.02)

  

0.84 (0.68, 1.05)

  

1.02 (0.85, 1.22)

 Current smoker*FRP

   

1.16 (0.99, 1.35)

  

0.99 (0.74, 1.32)

  

1.36 (1.08, 1.71)

Categorical FRP

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

1-year FRP < 0.34%

1-year FRP ≥ 0.34%

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

HR (95% CI)

 Never smoker

Reference

Reference

Reference

Reference

Reference

Reference

 Former smoker

1.11 (0.87, 1.43)

1.03 (0.87, 1.23)

0.97 (0.65, 1.45)

0.98 (0.74, 1.28)

0.80 (0.31, 2.04)

0.94 (0.61, 1.44)

 Current smoker

0.91 (0.64, 1.28)

1.09 (0.87, 1.37)

0.90 (0.52, 1.57)

1.13 (0.79, 1.61)

0.87 (0.29, 2.67)

1.18 (0.72, 1.93)

  1. BC breast cancer, HR hazard ratio, CI confidence interval, ER estrogen receptor expression, FRP familial risk profile
  2. aModel 1 = Adjusted Cox models which are stratified by birth cohort (< 1950, 1950–1959, 1960–1969, ≥ 1970) and adjusted for study site, race/ethnicity, body mass index, education, and hormonal birth control use
  3. bModel 2 = Interaction models that include an interaction term with FRP as estimated by 1-year BOADICEA risk score
  4. cSmokers are defined as having smoked at least one cigarette per day for 3 months or longer
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Breast Cancer Research

ISSN: 1465-542X

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