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Table 2 Adjusted hazard ratios and 95% confidence intervals from Cox proportional hazards modeling of smoking status

From: Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC)

 Overall BCER-positive BCER-negative BC
Continuous FRPPerson yearsBCModel 1aModel 2bBCModel 1aModel 2bBCModel 1aModel 2b
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
 Never smoker c102,781.5559ReferenceReference235ReferenceReference85ReferenceReference
 Former smoker47,088.83021.06 (0.92, 1.22)1.14 (0.96, 1.34)1180.97 (0.77, 1.21)1.09 (0.84, 1.43)390.95 (0.63, 1.41)0.92 (0.59, 1.45)
 Current smoker26,466.71371.02 (0.85, 1.23)0.92 (0.73, 1.15)541.04 (0.77, 1.40)1.05 (0.73, 1.51)271.22 (0.78, 1.91)0.81 (0.46, 1.43)
 Former smoker*FRP   0.91 (0.81, 1.02)  0.84 (0.68, 1.05)  1.02 (0.85, 1.22)
 Current smoker*FRP   1.16 (0.99, 1.35)  0.99 (0.74, 1.32)  1.36 (1.08, 1.71)
Categorical FRP1-year FRP < 0.34%1-year FRP ≥ 0.34%1-year FRP < 0.34%1-year FRP ≥ 0.34%1-year FRP < 0.34%1-year FRP ≥ 0.34%
HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)HR (95% CI)
 Never smokerReferenceReferenceReferenceReferenceReferenceReference
 Former smoker1.11 (0.87, 1.43)1.03 (0.87, 1.23)0.97 (0.65, 1.45)0.98 (0.74, 1.28)0.80 (0.31, 2.04)0.94 (0.61, 1.44)
 Current smoker0.91 (0.64, 1.28)1.09 (0.87, 1.37)0.90 (0.52, 1.57)1.13 (0.79, 1.61)0.87 (0.29, 2.67)1.18 (0.72, 1.93)
  1. BC breast cancer, HR hazard ratio, CI confidence interval, ER estrogen receptor expression, FRP familial risk profile
  2. aModel 1 = Adjusted Cox models which are stratified by birth cohort (< 1950, 1950–1959, 1960–1969, ≥ 1970) and adjusted for study site, race/ethnicity, body mass index, education, and hormonal birth control use
  3. bModel 2 = Interaction models that include an interaction term with FRP as estimated by 1-year BOADICEA risk score
  4. cSmokers are defined as having smoked at least one cigarette per day for 3 months or longer