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Table 1 Risk factors and clinical characteristics of cases and controls. Cases are also shown stratified by tumor size

From: Automated volumetric breast density measures: differential change between breasts in women with and without breast cancer

  Overall cases (N = 1160) Tumor size  
≤ 2 cm (N = 860) 2.1–5 cm (N = 243) > 5 cm (N = 36) Controls (N = 2360)
Age, median (Q1, Q3)* 61.0 (53, 70) 61.1 (53, 71) 60.0 (52, 69) 57.7 (50, 67) 61.4 (54, 70)
Body mass index, median (Q1, Q3)* 25.8 (22.7, 30.5) 25.8 (22.8, 30.3) 26.4 (22.5, 30.8) 28.6 (24.4, 32.9) 25.8 (22.9, 30.2)
Race
 White 943 (81.3%) 706 (82.1%) 193 (79.4%) 32 (88.9%) 2028 (85.9%)
 Asian 139 (12.0%) 95 (11.0%) 37 (15.2%) 2 (5.6%) 203 (8.6%)
 African-American 26 (2.2%) 18 (2.1%) 6 (2.5%) 0 (0.0%) 39 (1.7%)
 Hispanic 21 (1.8%) 17 (2.0%) 3 (1.2%) 0 (0.0%) 43 (1.8%)
 Others/mixed 31 (2.7%) 24 (2.8%) 4 (1.6%) 2 (5.6%) 47 (2.0%)
Interval between mammograms, median (Q1, Q3) 3.0 (1.9, 3.9) 3.0 (1.9, 4.0) 3.0 (1.9, 3.9) 2.9 (1.6, 3.9) 3.1 (2.0, 4.1)
First degree family Hx B.C.* 317 (27.6%) 247 (29.1%) 59 (24.5%) 6 (16.7%) 479 (20.4%)
Post-menopausal* (age 55+) 805 (69.4%) 605 (70.3%) 161 (66.3%) 21 (58.3%) 1675 (71.0%)
Screening mammogram within 2 months of diagnosis 1043 (90%) 784 (91%) 212 (87%) 27 (75%)
BI-RADS density*
 a 132 (12.9%) 107 (14.1%) 20 (9.5%) 3 (10.0%) 463 (20.5%)
 b 408 (40.0%) 309 (40.6%) 81 (38.6%) 9 (30.0%) 973 (43.1%)
 c 391 (38.3%) 275 (36.1%) 94 (44.8%) 17 (56.7%) 684 (30.3%)
 d 89 (8.7%) 70 (9.2%) 15 (7.1%) 1 (3.3%) 138 (6.1%)
VPD (%)*
 Median 6.9 6.6 8.1 9.0 5.9
 Q1, Q3 4.8, 11.3 4.6, 10.8 5.2, 12.9 5.7, 12.8 4.3, 9.7
 Range (2.3–36.0) (2.3–36.0) (2.4–29.7) (3.3–24.8) (2.0–36.3)
DV (cm3)*
 Median 56.0 53.5 62.6 81.6 47.7
 Q1, Q3 41.5, 79.4 40.0, 73.5 45.1, 90.4 62.2, 110.7 35.9, 64.8
 Range (12.4–281.1) (12.4–265.4) (17.7–212.6) (22.2–199.2) (10.8–314.8)
  1. Twenty-one case subjects with unknown tumor size, 50 case subjects with unknown BMI, 13 case subjects with unknown family history, 140 subjects with unknown BI-RADS density
  2. BI-RADS Breast Imaging Reporting and Data System 4th edition, VPD volumetric percent density, DV dense volume
  3. *Determined at the time of the earliest mammogram