Table 2 Univariate analysis of OS and DFS in the TNBC patients treated with chemotherapy
Variables | OS | DFS | ||||||
|---|---|---|---|---|---|---|---|---|
No. | HR | 95% CI | P value | No. | HR | 95% CI | P value | |
NR1D1 expression | ||||||||
Low | 122 | 1.00 | 123 | 1.00 | ||||
High | 37 | 0.09 | 0.01–0.63 | 0.016 | 37 | 0.17 | 0.04–0.73 | 0.017 |
Age at diagnosis | ||||||||
≤ 50 | 109 | 1.00 | 110 | 1.00 | ||||
> 50 | 50 | 1.25 | 0.62–2.55 | 0.535 | 50 | 0.80 | 0.37–1.71 | 0.564 |
Tumor size | ||||||||
T1 | 55 | 1.00 | 56 | 1.00 | ||||
T2 | 93 | 2.16 | 0.87–5.36 | 0.096 | 93 | 2.09 | 0.89–4.86 | 0.089 |
T3 or T4 | 11 | 7.63 | 2.46–23.70 | < 0.001 | 11 | 4.58 | 1.34–15.68 | 0.015 |
LN involvement | ||||||||
N0 | 93 | 1.00 | 94 | 1.00 | ||||
N1 | 36 | 1.03 | 0.36–2.94 | 0.950 | 36 | 0.77 | 0.28–2.10 | 0.607 |
N2 | 17 | 3.01 | 1.13–8.04 | 0.028 | 17 | 2.18 | 0.85–5.57 | 0.105 |
N3 | 13 | 15.26 | 6.46–36.05 | < 0.001 | 13 | 7.99 | 3.23–19.79 | < 0.001 |
LN Metastasis | ||||||||
No | 93 | 1.00 | 94 | 1.00 | ||||
Yes | 66 | 2.79 | 1.37–5.66 | 0.005 | 66 | 1.77 | 0.90–3.46 | 0.099 |
AJCC stage | ||||||||
I | 42 | 1.00 | 43 | 1.00 | ||||
II | 84 | 1.55 | 0.50–4.74 | 0.446 | 84 | 1.64 | 0.60–4.48 | 0.333 |
III | 33 | 6.65 | 2.22–19.93 | < 0.001 | 33 | 4.49 | 1.60–12.63 | 0.004 |
Histologic grade | ||||||||
1 | 3 | – | 3 | – | ||||
2 | 31 | 1.00 | 31 | 1.00 | ||||
3 | 99 | 1.86 | 0.64–5.39 | 0.251 | 100 | 1.57 | 0.60–4.14 | 0.358 |
Unknown | 26 | – | – | – | 26 | – | – | – |