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Fig. 6 | Breast Cancer Research

Fig. 6

From: Investigating circulating tumor cells and distant metastases in patient-derived orthotopic xenograft models of triple-negative breast cancer

Fig. 6

Epithelial, mesenchymal, and mixed phenotypes of CTCs isolated from a metastatic TNBC PDOX model. a Fluorescent images of CTCs isolated from a mouse bearing PDOX tumor SUTI151 captured using the Vortex platform and probed for the epithelial marker (cytokeratin, CK) and the mesenchymal marker (vimentin, VIM). Nuclei were highlighted with DAPI. CTCs were identified as DAPI positive, positive for CK and/or VIM, and negative for CD45. b Graph representing the percentage of CTCs staining positive for CK and/or VIM from two individual mouse models (#1, #2) bearing the same PDOX SUTI151 tumor, with the majority of CTCs showing a mixed epithelial and mesenchymal phenotype

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