Fig. 2

Somatic mutations in MPA/DMBA-induced mouse mammary tumors. a The MPA/DMBA-induced tumors carried between 288 and 1795 exonic mutations. No significant differences in mutational burden were found between the clusters; however, a high mutational rate was observed in the two squamous-like^Ex tumors. b Nf1, Trp53, Atr, and Fat1 were the most frequently mutated driver genes in the MPA/DMBA-induced tumor cohort. No specific mutations accurately delineated the tumor clusters. c MPA/DMBA-induced tumors generally showed divergent mutational rates compared to human breast cancer in the genes most frequently mutated in human breast cancer. TP53 mutations occurred at a similar rate in MPA/DMBA-induced tumors and human breast cancer