Fig. 4
From: Vasculogenic mimicry is associated with trastuzumab resistance of HER2-positive breast cancer
Generation of Tzm-resistant HER2+ breast cancer cells. a Morphology of parental cells and cells treated with Tzm for more than 6 months. Note that the BT474 cells loaded with Tzm formed clusters that were not adherent to culture vessels. Scale bar, 0.5 mm. b Tzm sensitivity assay. Dose-response curves of SKBR3 cells and BT474 cells (n = 4; mean ± SD) are shown. c Expression of CD144 (VE-cadherin) in Tzm-resistant SKBR3 cells and BT474 cells compared with parental cells