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Table 1 Distribution of circulating IGF-I and IGFBPs 1–7 (ng/ml) among BREAST Stamp Project participants, stratified by menopausal status

From: Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

IGF measure QC measures Premenopausal (N = 193) Postmenopausal (N = 103)
CV (%) ICC (%) Median1 10th percentile 90th percentile Median 10th percentile 90th percentile
IGF-I 2.03 99.6 120 83.7 182 111 72.5 143
IGFBP-12 7.50 99.0 2.05 0.03 6.39 1.86 0.03 7.31
IGFBP-2 3.75 99.4 341 177 639 357 149 616
IGFBP-3 6.19 92.2 3502 2715 4455 3519 2676 4508
IGFBP-4 5.70 95.3 130 99 176 156 117 218
IGFBP-5 5.32 96.1 387 280 508 402 291 521
IGFBP-6 5.45 94.2 188 143 240 176 128 238
IGFBP-7 5.43 92.2 105 86.2 134 115 99.1 139
  1. CV coefficient of variation, ICC intraclass correlation coefficient, IGF insulin-like growth factor, IGFBP IGF binding protein
  2. 1Median and 10 and 90th percentiles were calculated using untransformed IGF measures
  3. 2For IGFBP-1, N = 91 samples were below the lower limit of detection (LLOD) and were reassigned as ½ LLOD (0.025)