Relationship of circulating insulin-like growth factor-I and binding proteins 1–7 with mammographic density among women undergoing image-guided diagnostic breast biopsy

Table 1 Distribution of circulating IGF-I and IGFBPs 1–7 (ng/ml) among BREAST Stamp Project participants, stratified by menopausal status

IGF measure	QC measures		Premenopausal (N = 193)			Postmenopausal (N = 103)
IGF measure	CV (%)	ICC (%)	Median¹	10th percentile	90th percentile	Median	10th percentile	90th percentile
IGF-I	2.03	99.6	120	83.7	182	111	72.5	143
IGFBP-1²	7.50	99.0	2.05	0.03	6.39	1.86	0.03	7.31
IGFBP-2	3.75	99.4	341	177	639	357	149	616
IGFBP-3	6.19	92.2	3502	2715	4455	3519	2676	4508
IGFBP-4	5.70	95.3	130	99	176	156	117	218
IGFBP-5	5.32	96.1	387	280	508	402	291	521
IGFBP-6	5.45	94.2	188	143	240	176	128	238
IGFBP-7	5.43	92.2	105	86.2	134	115	99.1	139

CV coefficient of variation, ICC intraclass correlation coefficient, IGF insulin-like growth factor, IGFBP IGF binding protein
¹Median and 10 and 90th percentiles were calculated using untransformed IGF measures
²For IGFBP-1, N = 91 samples were below the lower limit of detection (LLOD) and were reassigned as ½ LLOD (0.025)

ISSN: 1465-542X