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Table 3 Pathways over-represented in the first-order 812 gene network

From: Gene expression signature of atypical breast hyperplasia and regulation by SFRP1

Pathway

Total

Expected

Hits

p value

FDR

Pathways in cancer

310

80.9

197

6.53E−47

1.42E−44

ErbB signaling pathway

87

22.7

70

1.35E−26

1.47E−24

Chronic myeloid leukemia

73

19.1

62

3.38E−26

2.45E−24

HTLV-I infection

199

52

121

5.30E−26

2.78E−24

WNT signaling pathway

144

37.6

97

6.41E−26

2.78E−24

Focal adhesion

200

52.2

117

4.23E−23

1.53E−21

Pancreatic cancer

69

18

56

8.10E−22

2.51E−20

Neurotrophin signaling pathway

123

32.1

82

1.39E−21

3.78E−20

Prostate cancer

87

22.7

64

1.27E−20

3.07E−19

Colorectal cancer

49

12.8

43

1.21E−19

2.63E−18

Osteoclast differentiation

119

31.1

77

3.84E−19

7.58E−18

Acute myeloid leukemia

57

14.9

47

4.98E−19

9.01E−18

Hepatitis C

100

26.1

68

8.76E−19

1.46E−17

T cell receptor signaling pathway

98

25.6

67

1.02E−18

1.58E−17

Melanogenesis

101

26.4

68

2.02E−18

2.92E−17

Regulation of actin cytoskeleton

182

47.5

102

2.39E−18

3.24E−17

Chagas disease (American trypanosomiasis)

89

23.2

62

4.82E−18

6.15E−17

MAPK signaling pathway

265

69.2

132

1.51E−17

1.82E−16

B cell receptor signaling pathway

75

19.6

54

7.04E−17

8.04E−16

Gap junction

89

23.2

60

1.99E−16

2.16E−15

Renal cell carcinoma

60

15.7

46

2.51E−16

2.60E−15

Epstein-Barr virus infection

91

23.8

60

9.93E−16

9.79E−15

Cell cycle

124

32.4

74

1.37E−15

1.30E−14

Axon guidance

118

30.8

71

2.90E−15

2.62E−14

Toll-like receptor signaling pathway

97

25.3

62

3.02E−15

2.62E−14

Glioma

65

17

47

5.85E−15

4.88E−14

Herpes simplex infection

103

26.9

64

7.95E−15

6.39E−14