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Table 3 Pathways over-represented in the first-order 812 gene network

From: Gene expression signature of atypical breast hyperplasia and regulation by SFRP1

Pathway Total Expected Hits p value FDR
Pathways in cancer 310 80.9 197 6.53E−47 1.42E−44
ErbB signaling pathway 87 22.7 70 1.35E−26 1.47E−24
Chronic myeloid leukemia 73 19.1 62 3.38E−26 2.45E−24
HTLV-I infection 199 52 121 5.30E−26 2.78E−24
WNT signaling pathway 144 37.6 97 6.41E−26 2.78E−24
Focal adhesion 200 52.2 117 4.23E−23 1.53E−21
Pancreatic cancer 69 18 56 8.10E−22 2.51E−20
Neurotrophin signaling pathway 123 32.1 82 1.39E−21 3.78E−20
Prostate cancer 87 22.7 64 1.27E−20 3.07E−19
Colorectal cancer 49 12.8 43 1.21E−19 2.63E−18
Osteoclast differentiation 119 31.1 77 3.84E−19 7.58E−18
Acute myeloid leukemia 57 14.9 47 4.98E−19 9.01E−18
Hepatitis C 100 26.1 68 8.76E−19 1.46E−17
T cell receptor signaling pathway 98 25.6 67 1.02E−18 1.58E−17
Melanogenesis 101 26.4 68 2.02E−18 2.92E−17
Regulation of actin cytoskeleton 182 47.5 102 2.39E−18 3.24E−17
Chagas disease (American trypanosomiasis) 89 23.2 62 4.82E−18 6.15E−17
MAPK signaling pathway 265 69.2 132 1.51E−17 1.82E−16
B cell receptor signaling pathway 75 19.6 54 7.04E−17 8.04E−16
Gap junction 89 23.2 60 1.99E−16 2.16E−15
Renal cell carcinoma 60 15.7 46 2.51E−16 2.60E−15
Epstein-Barr virus infection 91 23.8 60 9.93E−16 9.79E−15
Cell cycle 124 32.4 74 1.37E−15 1.30E−14
Axon guidance 118 30.8 71 2.90E−15 2.62E−14
Toll-like receptor signaling pathway 97 25.3 62 3.02E−15 2.62E−14
Glioma 65 17 47 5.85E−15 4.88E−14
Herpes simplex infection 103 26.9 64 7.95E−15 6.39E−14