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Fig. 3 | Breast Cancer Research

Fig. 3

From: Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation

Fig. 3

Expression of PI3K/AKT/mTOR signaling pathway markers in paired baseline and on-treatment samples. a IRS score for pAKT S473, pS6 S235/236, pS6 S240/244, and Ki-67 in paired baseline and on-treatment samples. b Expression of PI3K/AKT/mTOR signaling pathway markers in the two patients who demonstrated clinical benefit. Upper panel, patient with partial response in PIK3CA cohort; bottom panel, patient with stable disease in PTEN cohort

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