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Table 3 Pre-RT, post-RT, and RT-related pain by selected variables and CRP status

From: Association between C-reactive protein and radiotherapy-related pain in a tri-racial/ethnic population of breast cancer patients: a prospective cohort study

Variable Categories Pre-RT pain1 (N = 349) Post-RT pain1 (N = 335) RT-related pain2 (N = 262)
No (< 4) Yes (≥ 4)   No (< 4) Yes (≥ 4)   No Yes  
N % N % P 3 N % N % P 3 N % N % P 3
Total   290 83 59 17   233 70 102 30   203 77 59 23  
Race/ethnicity NHW 53 96 2 4 0.016 45 88 6 12 0.003 42 89 5 11 0.018
AA 58 82 13 18   42 60 28 40   37 66 19 34  
HW 179 80 44 20   146 68 68 32   124 78 35 22  
Age (years) < 50 75 81 17 19 0.639 51 60 34 40 0.027 46 69 21 31 0.045
≥ 50 215 84 42 16   182 73 68 27   157 81 38 19  
BMI (kg/m2) < 25 84 88 11 12 0.009 68 81 16 19 0.001 63 85 11 15 0.075
25–29.99 101 88 14 12   85 74 30 26   73 78 20 22  
≥ 30 105 75 34 25   80 59 56 41   67 71 28 29  
Sum of 12 comorbid conditions4 0 114 84 22 16 0.897 103 75 34 25 0.009 87 83 18 17 0.009
1 111 83 22 17   88 73 33 27   79 81 18 19  
2 48 83 10 17   32 57 24 43   28 64 16 36  
≥ 3 17 77 5 23   10 48 11 52   9 56 7 44  
HER2 Positive 18 62 11 38 0.004 16 59 11 41 0.294 10 71 4 29 0.676
Negative 220 84 42 16   177 69 79 31   155 76 48 24  
Chemotherapy None 159 85 27 15 0.140 128 72 50 28 0.455 115 80 29 20 0.416
Taxane 123 79 32 21   100 68 48 32   83 75 27 25  
Other 8 100 0 0   5 56 4 44   5 63 3 38  
Trastuzumab No 274 85 49 15 0.005 218 70 92 30 0.281 194 78 55 22 0.497
Yes 16 61 10 39   15 60 10 40   9 69 4 31  
Taxane+trastuzumab None/other chemo only 166 86 26 14 0.012 132 71 53 29 0.558 120 79 31 21 0.667
Either 109 82 24 18   87 68 40 32   74 75 25 25  
Both 15 62 9 38   14 61 9 39   9 75 3 25  
Axillary surgery None/SLNB 205 86 33 14 0.027 163 72 63 28 0.141 145 78 40 22 0.590
ALND 85 77 26 23   70 64 39 36   58 75 19 25  
RT fractionation Conventional 240 82 52 18 0.309 190 67 94 33 0.013 165 75 55 25 0.028
Hypo 50 88 7 12   43 84 8 16   38 90 4 10  
Total RT dose (Gy) < 60 92 89 11 11 0.045 74 80 19 20 0.014 66 84 13 16 0.123
≥ 60 198 80 48 20   159 66 83 34   137 75 46 25  
Pre-RT CRP (mg/L) < 10 256 85 45 15 0.006 210 73 79 27 0.001 183 79 48 21 0.056
≥ 10 30 68 14 32   20 48 22 52   17 63 10 37  
Post-RT CRP (mg/L) < 10 234 83 47 17 0.410 203 71 82 29 0.077 175 78 49 22 0.373
≥ 10 32 78 9 22   23 58 17 43   22 71 9 29  
RT-related CRP change (mg/L) ≤ 1 192 82 41 18 0.992 170 72 67 28 0.140 151 82 34 18 0.006
> 1 70 82 15 18   53 63 31 37   43 65 23 35  
  1. 1Pain score ≥ 4 (moderate or severe pain) was considered yes for clinically relevant pain
  2. 2Patients with pre-RT pain score < 4 and post-RT pain score ≥ 4 or < 4 were considered yes or no for RT-related pain
  3. 3P values were from the chi-square test or Fisher's exact test excluding missing. Significant findings are in italics
  4. 4Sum of 12 patient-reported comorbid conditions: diabetes, hypertension, heart disease, lung disease, thyroid disease, cirrhosis liver, stroke, chronic bronchitis, hepatitis, tuberculosis, and 2 others