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Table 4 Inhibition of SIRT1 expression enhances the chemo-sensitivities to ADM and PTX in breast cancer cells overexpressing NNMT

From: Nicotinamide N-methyltransferase enhances chemoresistance in breast cancer through SIRT1 protein stabilization

 

ADM (μM)

PTX (nM)

Cell lines

Mean ± SEM

Fold change

Mean ± SEM

Fold change

SK-BR-3/NNMT-2

1.02 ± 0.09

 

25.63 ± 2.06

 

SK-BR-3/NNMT-2+EX527

0.88 ± 0.08

0.86

21.10 ± 1.67

0.82

SK-BR-3/NNMT-2+SIRT1 siRNA

0.49 ± 0.06**

0.48

17.37 ± 1.56*

0.68

MCF7/NNMT-2

0.95 ± 0.08

 

31.92 ± 2.49

 

MCF7/NNMT-2+EX527

0.53 ± 0.06*

0.56

25.15 ± 1.53

0.79

MCF7/NNMT-2+SIRT1 siRNA

0.35 ± 0.05**

0.37

21.95 ± 1.39*

0.69

MDA-MB-231

1.23 ± 0.09

 

12.40 ± 1.13

 

MDA-MB-231+EX527

0.92 ± 0.11

0.75

7.20 ± 0.78*

0.58

MDA-MB-231+SIRT1 siRNA

0.64 ± 0.05**

0.52

6.10 ± 0.74**

0.49

  1. Data represent the mean ± SEM of three independent experiments. Statistical significance was detected between the EX527, SIRT1 siRNA groups, and control groups treated only with DMSO
  2. *p < 0.05, **p < 0.01
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Breast Cancer Research

ISSN: 1465-542X

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