Identification of three subtypes of triple-negative breast cancer with potential therapeutic implications

Breast Cancer Research

Table 2 C2 vs C3 CIBERSORT analysis results

Immune cells	Tumorigenic effect in breast cancer^a	P	C2 vs C3 differential expression
B cells memory	Pro-tumorigenic	0.0242	C2 > C3
B cells naïve	No effect	0.0798	C2 ≈ C3
Dendritic cells activated	Anti-tumorigenic	0.0177	C2 > C3
Dendritic cells resting	Pro-tumorigenic	0.4011	C2 ≈ C3
Eosinophils	Pro-tumorigenic	0.0243	C2 > C3
Macrophages M0	Pro-tumorigenic	< 0.0001	C2 > C3
Macrophages M1	Anti-tumorigenic	0.0005	C2 < C3
Macrophages M2	Pro-tumorigenic	< 0.0001	C2 > C3
Mast cells activated	Pro-tumorigenic	< 0.0001	C2 > C3
Mast cells resting	Anti-tumorigenic	0.0414	C2 < C3
Monocytes	Pro-tumorigenic	0.0169	C2 > C3
Neutrophils	Pro-tumorigenic	0.4571	C2 ≈ C3
NK cells activated	Anti-tumorigenic	0.5534	C2 ≈ C3
NK cells resting	Pro-tumorigenic	0.3776	C2 ≈ C3
Plasma cells	Anti-tumorigenic	< 0.0001	C2 < C3
T cells CD4 memory activated	Anti-tumorigenic	< 0.0001	C2 < C3
T cells CD4 memory resting	Pro-tumorigenic	0.0481	C2 > C3
T cells CD4 naive	Anti-tumorigenic	0.2901	C2 ≈ C3
T cells CD8	Anti-tumorigenic	0.0001	C2 < C3
T cells follicular helper	Anti-tumorigenic	0.2394	C2 ≈ C3
T cells gamma delta	Anti-tumorigenic	< 0.0001	C2 < C3
T cells regulatory	Anti-tumorigenic	0.4372	C2 ≈ C3

ISSN: 1465-542X