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Table 1 ER status and cytonuclear grade of DCIS by age

From: Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years

Age Total ER+ ER− ER unknown High grade Int grade Low grade Grade unknown
40–49 555 345 (62%) 62 (11%) 148 (27%) 345 (62%) 148 (27%) 47 (8%) 15 (3%)
< 40 100 45 (45%) 26 (26%) 29 (29%) 72 (72%) 20 (20%) 7 (7%) 1 (1%)
All 655 390 88 177 417 168 54 16