From: Frequency of pathogenic germline variants in BRCA1, BRCA2, PALB2, CHEK2 and TP53 in ductal carcinoma in situ diagnosed in women under the age of 50 years
Age
Total
ER+
ER−
ER unknown
High grade
Int grade
Low grade
Grade unknown
40–49
555
345 (62%)
62 (11%)
148 (27%)
47 (8%)
15 (3%)
< 40
100
45 (45%)
26 (26%)
29 (29%)
72 (72%)
20 (20%)
7 (7%)
1 (1%)
All
655
390
88
177
417
168
54
16