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Fig. 2 | Breast Cancer Research

Fig. 2

From: Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

Fig. 2

Expression of genes involved in glutaminolysis from untreated MAS98.06 and MAS98.12 tumors. a Heatmap of expression of the 60 selected genes involved in glutaminolysis in untreated MAS98.06 and MAS98.12 tumors. b Differences in gene expression between untreated MAS98.06 and MAS98.12 xenografts. Blue, the gene is significantly higher expressed with at least a two-fold higher expression in MAS98.06; red, the gene is significantly higher expressed with at least two-fold higher expression in MAS98.12; white, the gene is not significantly different expressed between the models. Log2-fold change (log2FC) between the two models is indicated by color intensity. Dotted arrows from Myc indicate some of the most important genes that are positively (+) and negatively (−) regulated by Myc, as shown by others [4, 26, 34,35,36]. Full gene names, enzyme commission numbers (EC numbers), gene expression levels, q values, log2 fold change, and fold changes are specified in Additional file 5

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