Table 2 Associations (odds ratios, OR) for adjusted percent density (PD) and dense area (DA) measures with breast cancer risk, with or without polygenic risk score (PRS). All eight studies and restricted to cohort/population-based studies only
Adjusted density measure* | Full sample | Cohort/population-based studies only | ||||
|---|---|---|---|---|---|---|
N case/N control | OR (95% CI) | Adj for PRS OR (95% CI) | N case/N control | OR (95% CI) | Adj for PRS OR (95% CI) | |
PD (per 1 SD) | 3628/5126 | 1.45 (1.38, 1.52) | 1.42 (1.36, 1.50) | 2439/3895 | 1.42 (1.34, 1.50) | 1.40 (1.32, 1.48) |
PD quartiles | ||||||
 1 | 531/1282 | 0.60 (0.52, 0.70) | 0.61 (0.52, 0.70) | 450/1064 | 0.61 (0.51, 0.72) | 0.62 (0.52, 0.73) |
 2 (Ref) | 723/1281 | Ref | Ref | 519/984 | Ref | Ref |
 3 | 946/1282 | 1.25 (1.09, 1.42) | 1.22 (1.06, 1.39) | 615/939 | 1.20 (1.03, 1.41) | 1.18 (1.00, 1.38) |
 4 | 1428/1281 | 1.64 (1.44, 1.87) | 1.60 (1.40, 1.82) | 855/908 | 1.51 (1.29, 1.76) | 1.48 (1.27, 1.74) |
DA (per 1 SD) | 3628/5126 | 1.34 (1.28, 1.41) | 1.32 (1.26, 1.39) | 2439/3895 | 1.36 (1.29, 1.44) | 1.35 (1.28, 1.44) |
DA quartiles | ||||||
 1 | 530/1283 | 0.56 (0.49, 0.65) | 0.57 (0.50, 0.66) | 427/1040 | 0.58 (0.40, 0.69) | 0.59 (0.50, 0.70) |
 2 (Ref) | 764/1281 | Ref | Ref | 535/1003 | Ref | Ref |
 3 | 964/1281 | 1.15 (1.01, 1.31) | 1.15 (1.00, 1.31) | 644/969 | 1.14 (0.98, 1.33) | 1.13 (0.97, 1.33) |
 4 | 1370/1281 | 1.41 (1.23, 1.61) | 1.38 (1.21, 1.59) | 833/883 | 1.45 (1.24, 1.69) | 1.44 (1.22, 1.69) |