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Table 2 Associations (odds ratios, OR) for adjusted percent density (PD) and dense area (DA) measures with breast cancer risk, with or without polygenic risk score (PRS). All eight studies and restricted to cohort/population-based studies only

From: Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk

Adjusted density measure* Full sample Cohort/population-based studies only
N case/N control OR (95% CI) Adj for PRS
OR (95% CI)
N case/N control OR (95% CI) Adj for PRS
OR (95% CI)
PD (per 1 SD) 3628/5126 1.45 (1.38, 1.52) 1.42 (1.36, 1.50) 2439/3895 1.42 (1.34, 1.50) 1.40 (1.32, 1.48)
PD quartiles
 1 531/1282 0.60 (0.52, 0.70) 0.61 (0.52, 0.70) 450/1064 0.61 (0.51, 0.72) 0.62 (0.52, 0.73)
 2 (Ref) 723/1281 Ref Ref 519/984 Ref Ref
 3 946/1282 1.25 (1.09, 1.42) 1.22 (1.06, 1.39) 615/939 1.20 (1.03, 1.41) 1.18 (1.00, 1.38)
 4 1428/1281 1.64 (1.44, 1.87) 1.60 (1.40, 1.82) 855/908 1.51 (1.29, 1.76) 1.48 (1.27, 1.74)
DA (per 1 SD) 3628/5126 1.34 (1.28, 1.41) 1.32 (1.26, 1.39) 2439/3895 1.36 (1.29, 1.44) 1.35 (1.28, 1.44)
DA quartiles
 1 530/1283 0.56 (0.49, 0.65) 0.57 (0.50, 0.66) 427/1040 0.58 (0.40, 0.69) 0.59 (0.50, 0.70)
 2 (Ref) 764/1281 Ref Ref 535/1003 Ref Ref
 3 964/1281 1.15 (1.01, 1.31) 1.15 (1.00, 1.31) 644/969 1.14 (0.98, 1.33) 1.13 (0.97, 1.33)
 4 1370/1281 1.41 (1.23, 1.61) 1.38 (1.21, 1.59) 833/883 1.45 (1.24, 1.69) 1.44 (1.22, 1.69)
  1. *Residuals from models adjusted for age, 1/BMI, and study
  2. Heterogeneity of density association across population-based studies: PD phet = 0.08; DA phet = 0.04 (Exclusion of MMHS results in PD phet = 0.42; DA phet = 0.25)
  3. SD standard deviation, CI confidence interval, Ref reference group, Adj adjusted