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Fig. 2 | Breast Cancer Research

Fig. 2

From: Regular use of aspirin and other non-steroidal anti-inflammatory drugs and breast cancer risk for women at familial or genetic risk: a cohort study

Fig. 2

Adjusted hazard ratios and 95% confidence intervals of breast cancer risk comparing regular users of aspirin and COX-2 inhibitors with non-regular users by subgroups from analysis of the combined cohort of the Prospective Family Study Cohort (N = 8233). Legend: Models are adjusted for race/ethnicity, study center, baseline age, familial risk profile, cigarette smoking, alcohol consumption, hormone therapy use, hormonal birth control use, and regular use of other medications; stratified by birth cohort. Sample sizes: non-carriers (includes true negatives and women who did not undergo genetic testing) N = 6395; BRCA1 mutation carriers N = 506; BRCA2 mutation carriers N = 418; ER status: N = 7319; attained age 45: N = 2222; attained age 55: N = 4401; attained age 65: N = 6325. Alternative ER subtypes were censored at diagnosis (e.g., ER negative and ER status missing breast cancers censored at age at diagnosis in the analysis of ER positive breast cancer). P values are for the Wald chi-square test statistic for the interaction between categories of familial risk profile or BRCA carrier status and regular medication use

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