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Fig. 5 | Breast Cancer Research

Fig. 5

From: The pro- and anti-tumor roles of mesenchymal stem cells toward BRCA1-IRIS-overexpressing TNBC cells

Fig. 5

IRISOE TNBC tumor cells skew MSCs toward the PGE2-secreting fibrogenic fate, in vitro. Percentage of MSCs stained with Oil Red (a), Alizarin Red S (b), and PicroSirius (c) in cultures exposed to HME, IRIS291, IRIS293 cells, MDA-231/shCtrl, MDA-231/shIRIS, MDA-468/shCtrl, and MDA-468/shIRIS cell CM. d The secretion of PGE2 from naïve MSCs (black) or MSCs chemically differentiated to adipogenic, osteogenic, chondrogenic, or fibrogenic fates, before they were exposed to hypoxic HME (blue), hypoxic IRIS291 (orange), hypoxic IRIS292 (yellow), or hypoxic IRIS293 (red) cell CM

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