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Table 2 Genes differentially expressed between parous and nulliparous premenopausal women (discovery/validation approach)

From: Genomic signature of parity in the breast of premenopausal women

ProbeID EntrezID Symbol GeneName FDR Fold change
Genes upregulated in parous women
 206641_at 608 TNFRSF17 Tumor necrosis factor receptor superfamily, member 17 0.013 2.41
 228504_at 6332 SCN7A Sodium channel, voltage-gated, type VII, alpha subunit 0.006 2.15
 237625_s_at 3514 IGKC Immunoglobulin kappa constant 0.006 1.94
 222838_at 57823 SLAMF7 SLAM family member 7 0.017 1.93
 224342_x_at 96610 LOC96610 BMS1 homolog, ribosome assembly protein (yeast) pseudogene 0.032 1.80
 206121_at 270 AMPD1 Adenosine monophosphate deaminase 1 0.021 1.76
 206033_s_at 1825 DSC3 Desmocollin 3 0.006 1.68
 1555759_a_at 6352 CCL5 Chemokine (C-C motif) ligand 5 0.018 1.67
 206478_at 9834 KIAA0125 KIAA0125 0.006 1.65
 213193_x_at 28639 TRBC1 T cell receptor beta constant 1 0.006 1.60
 207651_at 29909 GPR171 G protein-coupled receptor 171 0.014 1.60
 206310_at 6691 SPINK2 Serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 0.006 1.59
 231647_s_at 83416 FCRL5 Fc receptor-like 5 0.012 1.59
 203130_s_at 3800 KIF5C Kinesin family member 5C 0.023 1.58
 205831_at 914 CD2 CD2 molecule 0.012 1.54
 216430_x_at 28823 IGLV1-44 Immunoglobulin lambda variable 1-44 0.034 1.52
 211339_s_at 3702 ITK IL2-inducible T cell kinase 0.016 1.50
 206666_at 3003 GZMK Granzyme K (granzyme 3; tryptase II) 0.030 1.49
 204562_at 3662 IRF4 Interferon regulatory factor 4 0.017 1.47
 213539_at 915 CD3D CD3d molecule, delta (CD3-TCR complex) 0.011 1.45
 206181_at 6504 SLAMF1 Signaling lymphocytic activation molecule family member 1 0.014 1.45
 206150_at 939 CD27 CD27 molecule 0.019 1.44
 206991_s_at 1234 CCR5 Chemokine (C-C motif) receptor 5 (gene/pseudogene) 0.010 1.41
 235153_at 138065 RNF183 Ring finger protein 183 0.026 1.41
 214470_at 3820 KLRB1 Killer cell lectin-like receptor subfamily B, member 1 0.038 1.40
 230011_at 150365 MEI1 Meiosis inhibitor 1 0.010 1.39
 211902_x_at 10730 YME1L1 YME1-like 1 (S. cerevisiae) 0.015 1.37
 221584_s_at 3778 KCNMA1 Potassium large conductance calcium-activated channel, subfamily M, alpha member 1 0.034 1.36
 219551_at 55840 EAF2 ELL associated factor 2 0.015 1.35
 220402_at 63970 TP53AIP1 Tumor protein p53 regulated apoptosis inducing protein 1 0.015 1.35
 206761_at 10225 CD96 CD96 molecule 0.036 1.33
 212314_at 23231 SEL1L3 Sel-1 suppressor of lin-12-like 3 (C. elegans) 0.014 1.31
 204682_at 4053 LTBP2 Latent transforming growth factor beta binding protein 2 0.006 1.31
 207655_s_at 29760 BLNK B cell linker 0.015 1.31
 204205_at 60489 APOBEC3G Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G 0.014 1.26
 223322_at 83593 RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.024 1.25
 227405_s_at 8325 FZD8 Frizzled family receptor 8 0.024 1.24
 211469_s_at 10663 CXCR6 Chemokine (C-X-C motif) receptor 6 0.019 1.22
 233555_s_at 55959 SULF2 Sulfatase 2 0.032 1.20
 209574_s_at 753 LDLRAD4 Low-density lipoprotein receptor class A domain containing 4 0.045 1.15
Genes downregulated in parous women
 227475_at 94234 FOXQ1 Forkhead box Q1 0.026 0.64
 244680_at 2743 GLRB Glycine receptor, beta 0.046 0.79
 236399_at 54103 PION Pigeon homolog (Drosophila) 0.041 0.86