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Table 3 AUCs by subgroups

From: Breast cancer risk prediction in women aged 35–50 years: impact of including sex hormone concentrations in the Gail model

  BCRATa Gailb Gail + AMHb Gail + testosteroneb Gail + AMH + testosteroneb
Total AUC 55.0 (53.1, 56.8) 55.3 (53.4, 57.1) 57.6 (55.7, 59.5) 56.2 (54.4, 58.1) 58.1 (56.2, 59.9)
Age at blood donation, years
 ≤ 40 55.9 (52.3, 59.6) 56.2 (52.5, 59.8) 57.5 (53.8, 61.1) 57.3 (53.7, 61.0) 58.1 (54.4, 61.8)
 41–45 55.2 (52.2, 58.2) 54.9 (51.9, 57.9) 56.3 (53.3, 59.2) 56.0 (53.0, 58.9) 56.6 (53.7, 59.6)
 > 45 58.6 (55.4, 61.9) 58.6 (55.3, 61.9) 60.6 (57.4, 63.8) 60.9 (57.7, 64.1) 62.1 (58.9, 65.3)
Gail 5-year risk score, %
 < 1c 53.2 (50.2, 55.2) 52.9 (50.4, 55.4) 54.7 (52.2, 57.2) 54.3 (51.8, 56.8) 55.9 (53.4, 58.3)
 ≥ 1c 56.6 (53.7, 59.5) 58.2 (55.3, 61.0) 59.1 (56.3, 62.0) 57.4 (54.3, 60.5) 59.2 (56.3, 62.1)
Estrogen receptor status
 ER-positive 56.1 (53.8, 58.4) 56.4 (54.1, 58.8) 58.9 (56.2, 61.6) 57.2 (54.9, 59.5) 59.2 (56.3, 62.0)
 ER-negative 55.8 (51.1, 60.5) 56.8 (52.1, 61.5) 58.0 (53.3, 62.7) 57.1 (52.4, 61.8) 57.1 (52.3, 61.8)
Number of first-degree family members with breast cancer, n (%)
 0 52.2 (50.0, 54.3) 52.8 (50.6, 55.0) 55.6 (52.9, 58.3) 54.6 (52.4, 56.8) 56.8 (54.6, 58.9)
 ≥ 1 55.9 (52.1, 59.6) 55.0 (51.3, 58.7) 57.2 (53.4, 60.9) 56.4 (52.7, 60.1) 57.2 (52.0, 62.4)
  1. aEstimates from the model as implemented in BCRAT and using BCRAT regression coefficients
  2. bModel including Gail model variables and biomarker(s) and using regression coefficients in Table 2
  3. cMedian 5-year absolute risk was approximately 1%