| |
BCRATa
|
Gailb
|
Gail + AMHb
|
Gail + testosteroneb
|
Gail + AMH + testosteroneb
|
|---|
|
Total AUC
|
55.0 (53.1, 56.8)
|
55.3 (53.4, 57.1)
|
57.6 (55.7, 59.5)
|
56.2 (54.4, 58.1)
|
58.1 (56.2, 59.9)
|
|
Age at blood donation, years
|
|
≤ 40
|
55.9 (52.3, 59.6)
|
56.2 (52.5, 59.8)
|
57.5 (53.8, 61.1)
|
57.3 (53.7, 61.0)
|
58.1 (54.4, 61.8)
|
|
41–45
|
55.2 (52.2, 58.2)
|
54.9 (51.9, 57.9)
|
56.3 (53.3, 59.2)
|
56.0 (53.0, 58.9)
|
56.6 (53.7, 59.6)
|
|
> 45
|
58.6 (55.4, 61.9)
|
58.6 (55.3, 61.9)
|
60.6 (57.4, 63.8)
|
60.9 (57.7, 64.1)
|
62.1 (58.9, 65.3)
|
|
Gail 5-year risk score, %
|
|
< 1c
|
53.2 (50.2, 55.2)
|
52.9 (50.4, 55.4)
|
54.7 (52.2, 57.2)
|
54.3 (51.8, 56.8)
|
55.9 (53.4, 58.3)
|
|
≥ 1c
|
56.6 (53.7, 59.5)
|
58.2 (55.3, 61.0)
|
59.1 (56.3, 62.0)
|
57.4 (54.3, 60.5)
|
59.2 (56.3, 62.1)
|
|
Estrogen receptor status
|
|
ER-positive
|
56.1 (53.8, 58.4)
|
56.4 (54.1, 58.8)
|
58.9 (56.2, 61.6)
|
57.2 (54.9, 59.5)
|
59.2 (56.3, 62.0)
|
|
ER-negative
|
55.8 (51.1, 60.5)
|
56.8 (52.1, 61.5)
|
58.0 (53.3, 62.7)
|
57.1 (52.4, 61.8)
|
57.1 (52.3, 61.8)
|
|
Number of first-degree family members with breast cancer, n (%)
|
|
0
|
52.2 (50.0, 54.3)
|
52.8 (50.6, 55.0)
|
55.6 (52.9, 58.3)
|
54.6 (52.4, 56.8)
|
56.8 (54.6, 58.9)
|
|
≥ 1
|
55.9 (52.1, 59.6)
|
55.0 (51.3, 58.7)
|
57.2 (53.4, 60.9)
|
56.4 (52.7, 60.1)
|
57.2 (52.0, 62.4)
|
- aEstimates from the model as implemented in BCRAT and using BCRAT regression coefficients
- bModel including Gail model variables and biomarker(s) and using regression coefficients in Table 2
- cMedian 5-year absolute risk was approximately 1%
