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Table 2 Breast cancer recurrence and all-cause mortality, HR, and associated 95% CIs for women diagnosed with stage I–III, operable breast cancer in Denmark from 1996 to 2009 by hypothyroidism present at breast cancer diagnosis (prevalent) or during follow-up (incident)

From: Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study

  Recurrence All-cause mortality
Women with breast cancer (counts (%)) Recurrent events (counts (%)) Follow-up time (years) HR (95% CI) Women with breast cancer (counts (%)) All-cause mortality (counts (%)) Follow-up time (years) HR (95% CI)
Crude Adjusted Crude Adjusted
Prevalent hypothyroidism
 Normal thyroid 34,191 (96) 5626 (16) 20,288 1.00 1.00 34,225 (96) 9696 (96) 36,907 1.00 1.00
 Prevalent hypothyroidism 1272 (4) 184 (14) 594 0.94 (0.81–1.09) 1.01 (0.87–1.19)1 1273 (4) 398 (4) 1555 1.25 (1.13–1.39) 1.02 (0.92–1.14)1
Incident hypothyroidism
 Normal thyroid 33,332 (97) 5547 (17) 20,075 1.00 1.00 32,827 (96) 9422 (97) 36,599 1.00 1.00
 Incident hypothyroidism 859 (3) 79 (9) 213 1.00 (0.80–1.24) 0.93 (0.75–1.16)2 1398 (4) 274 (3) 307 1.15 (1.02–1.30) 1.08 (0.95–1.23)1
  1. HR hazard ratio
  2. 1Adjusted for age at diagnosis, UICC stage, ER/ET use, surgery type, receipt of chemotherapy, menopausal status, comorbidity, histologic grade, and use of simvastatin or aspirin (as time-varying covariates updated daily and lagged by 1 year), respectively. 2Adjusted for age at diagnosis, UICC stage, ER/ET status, type of primary surgery, and chemotherapy