Table 2 Breast cancer recurrence and all-cause mortality, HR, and associated 95% CIs for women diagnosed with stage I–III, operable breast cancer in Denmark from 1996 to 2009 by hypothyroidism present at breast cancer diagnosis (prevalent) or during follow-up (incident)
Recurrence | All-cause mortality | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Women with breast cancer (counts (%)) | Recurrent events (counts (%)) | Follow-up time (years) | HR (95% CI) | Women with breast cancer (counts (%)) | All-cause mortality (counts (%)) | Follow-up time (years) | HR (95% CI) | |||
Crude | Adjusted | Crude | Adjusted | |||||||
Prevalent hypothyroidism | ||||||||||
Normal thyroid | 34,191 (96) | 5626 (16) | 20,288 | 1.00 | 1.00 | 34,225 (96) | 9696 (96) | 36,907 | 1.00 | 1.00 |
Prevalent hypothyroidism | 1272 (4) | 184 (14) | 594 | 0.94 (0.81–1.09) | 1.01 (0.87–1.19)1 | 1273 (4) | 398 (4) | 1555 | 1.25 (1.13–1.39) | 1.02 (0.92–1.14)1 |
Incident hypothyroidism | ||||||||||
Normal thyroid | 33,332 (97) | 5547 (17) | 20,075 | 1.00 | 1.00 | 32,827 (96) | 9422 (97) | 36,599 | 1.00 | 1.00 |
Incident hypothyroidism | 859 (3) | 79 (9) | 213 | 1.00 (0.80–1.24) | 0.93 (0.75–1.16)2 | 1398 (4) | 274 (3) | 307 | 1.15 (1.02–1.30) | 1.08 (0.95–1.23)1 |