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Table 1 Pharmacokinetics of MEDI3039 in mice

From: MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

  Half-life Tmax Cmax Clast AUCall AUCINF_obs CL Vss
(h) (h) (ug/mL) (ug/mL) (ug h/mL) (ug h/mL) (mL/h/kg) (mL/kg)
MEDI3039 15.4 0.25 130.76 0.06 828.9 830.84 7.82 79.71