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Table 1 Pharmacokinetics of MEDI3039 in mice

From: MEDI3039, a novel highly potent tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptor 2 agonist, causes regression of orthotopic tumors and inhibits outgrowth of metastatic triple-negative breast cancer

 

Half-life

Tmax

Cmax

Clast

AUCall

AUCINF_obs

CL

Vss

(h)

(h)

(ug/mL)

(ug/mL)

(ug h/mL)

(ug h/mL)

(mL/h/kg)

(mL/kg)

MEDI3039

15.4

0.25

130.76

0.06

828.9

830.84

7.82

79.71

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Breast Cancer Research

ISSN: 1465-542X

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