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Table 4 Diagnostic performance of preoperative CE-MRI when different pCR definitions are used

From: Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR)

Percentage (95% CI) ypT0/is N0 ypT0/is ypT0 N0 ypT0 P value
pCR rate: 29% 32% 24% 28%
Sensitivity 75%
(63–84%)
73%
(62–82%)
76%
(63–86%)
75%
(63–85%)
0.980
Specificity 67%
(59–74%)
68%
(60–75%)
65%
(57–72%)
66%
(59–73%)
0.938
PPV 48%
(38–57%)
51%
(42–61%)
41%
(31–50%)
46%
(36–57%)
0.443
NPV 87%
(80–92%)
84%
(77–90%)
90%
(83–94%)
87%
(81–92%)
0.666
Accuracy 69%
(63–75%)
70%
(63–75%)
67%
(61–73%)
69%
(62–74%)
0.660
  1. CE-MRI contrast-enhanced magnetic resonance imaging, pCR pathologic complete response, PPV positive predictive value, NPV negative predictive value, ypT0/is N0 no invasive tumor in breast and axilla, ypT0/is no invasive tumor in the breast, ypT0 N0 no invasive or non-invasive tumor in the breast and axilla, ypT0no invasive or non-invasive tumor in the breast
  2. *Fisher’s exact test for all subgroups