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Table 4 Diagnostic performance of preoperative CE-MRI when different pCR definitions are used

From: Radiologic complete response (rCR) in contrast-enhanced magnetic resonance imaging (CE-MRI) after neoadjuvant chemotherapy for early breast cancer predicts recurrence-free survival but not pathologic complete response (pCR)

Percentage (95% CI)

ypT0/is N0

ypT0/is

ypT0 N0

ypT0

P value

pCR rate:

29%

32%

24%

28%

Sensitivity

75%

(63–84%)

73%

(62–82%)

76%

(63–86%)

75%

(63–85%)

0.980

Specificity

67%

(59–74%)

68%

(60–75%)

65%

(57–72%)

66%

(59–73%)

0.938

PPV

48%

(38–57%)

51%

(42–61%)

41%

(31–50%)

46%

(36–57%)

0.443

NPV

87%

(80–92%)

84%

(77–90%)

90%

(83–94%)

87%

(81–92%)

0.666

Accuracy

69%

(63–75%)

70%

(63–75%)

67%

(61–73%)

69%

(62–74%)

0.660

  1. CE-MRI contrast-enhanced magnetic resonance imaging, pCR pathologic complete response, PPV positive predictive value, NPV negative predictive value, ypT0/is N0 no invasive tumor in breast and axilla, ypT0/is no invasive tumor in the breast, ypT0 N0 no invasive or non-invasive tumor in the breast and axilla, ypT0no invasive or non-invasive tumor in the breast
  2. *Fisher’s exact test for all subgroups