Table 2 Diagnostic performance of preoperative CE-MRI in different molecular tumor subtypes
Percentage (95% CI) | All | Luminal A | Luminal B | HER2+/HR+ | HER2+/HR- | TNBC | P value* |
|---|---|---|---|---|---|---|---|
pCR rate | 29% | 5% | 28% | 30% | 49% | 37% | |
Sensitivity | 75% (63–84%) | 33% (1–91%) | 100% (56–100%) | 73% (39–94%) | 63% (35–85%) | 79% (61–91%) | 0.120 |
Specificity | 67% (59–74%) | 74% (60–85%) | 57% (32–76%) | 54% (33–73%) | 53% (28–77%) | 74% (60–84%) | 0.139 |
PPV | 48% (38–57%) | 7% (0.2–32) | 47% (22–69%) | 40% (19–64%) | 56% (31–78%) | 63% (47–78%) | 0.003 |
NPV | 87% (79–92%) | 95% (84–99%) | 100% (68–100%) | 82% (57–96%) | 60% (32–84%) | 86% (73–94%) | 0.009 |
Accuracy | 69% (63–75%) | 72% (58–83%) | 69% (49–84%) | 59% (42–75%) | 58% (39–74%) | 76% (65–84%) | < 0.001 |