Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds

Nguyen, Tuong L.; Aung, Ye K.; Li, Shuai; Trinh, Nhut Ho; Evans, Christopher F.; Baglietto, Laura; Krishnan, Kavitha; Dite, Gillian S.; Stone, Jennifer; English, Dallas R.; Song, Yun-Mi; Sung, Joohon; Jenkins, Mark A.; Southey, Melissa C.; Giles, Graham G.; Hopper, John L.

doi:10.1186/s13058-018-1081-0

Table 5 For interval and screen detected breast cancer, multivariable odds ratios, area under the receiving operating characteristic curve (AUC), and log likelihood (LL) for Cumulus, Altocumulus and Cirrocumulus measures of dense area and percent density adjusted for age and body mass index (BMI)

From: Predicting interval and screen-detected breast cancers from mammographic density defined by different brightness thresholds

		Interval cancer	P	LL	Screen-detected cancer	P	LL
		OPERA (95% CI)	P	LL	OPERA (95% CI)	P	LL
Dense area
Model 1^a	Cumulus	1.40 (1.15–1.72)	0.001	− 206.91	1.05 (0.94–1.19)	0.3	− 541.75
Model 1^a	Altocumulus	0.97 (0.80–1.18)	0.8	− 206.91	1.06 (0.94–1.19)	0.3	− 541.75
Model 2^b	Cumulus	1.16 (0.94–1.43)	0.2	− 204.46	0.98 (0.87–1.10)	0.8	− 538.16
Model 2^b	Cirrocumulus	1.26 (1.02–1.53)	0.03	− 204.46	1.19 (1.06–1.34)	0.005	− 538.16
Model 3^c	Altocumulus	0.94 (0.76–1.16)	0.6	− 205.27	0.98 (0.87–1.10)	0.8	− 538.18
Model 3^c	Cirrocumulus	1.49 (1.20–1.87)	< 0.001	− 205.27	1.19 (1.06–1.34)	0.005	− 538.18
Model 4^d	Cumulus	1.27 (0.99–1.62)	0.06	− 203.34	0.99 (0.85–1.14)	0.8	− 538.16
	Altocumulus	0.84 (0.65–1.07)	0.2		0.99 (0.86–1.15)	0.9
	Cirrocumulus	1.36 (1.07–1.72)	0.01		1.19 (1.04–1.36)	0.008
Percent density
Model 1^a	Cumulus	1.67 (1.36–2.07)	< 0.001	− 191.69	1.11 (0.99–1.25)	0.09	− 539.81
Model 1^a	Altocumulus	0.88 (0.72–1.07)	0.2	− 191.69	1.02 (0.91–1.15)	0.7	− 539.81
Model 2^b	Cumulus	1.48 (1.19–1.95)	< 0.001	− 192.00	1.02 (0.91–1.15)	0.7	− 536.68
Model 2^b	Cirrocumulus	1.10 (0.90–1.36)	0.3	− 192.00	1.17 (1.03–1.31)	0.01	− 536.68
Model 3^c	Altocumulus	1.05 (0.85–1.31)	0.6	− 198.33	0.99 (0.89–1.11)	0.9	− 536.74
Model 3^c	Cirrocumulus	1.43 (1.16–1.77)	0.001	− 198.33	1.20 (1.06–1.34)	0.003	− 536.74
Model 4^d	Cumulus	1.68 (1.30–2.19)	< 0.001	− 190.33	1.05 (0.90–1.27)	0.5	− 536.56
	Altocumulus	0.79 (0.61–1.02)	0.07		0.96 (0.82–1.12)	0.6
	Cirrocumulus	1.21 (0.96–1.52)	0.1		1.18 (1.04–1.34)	0.01

The change in odds ratio per adjusted standard deviation (OPERA) adjusted for age and body mass index is shown by quartiles (number of cases shown in parentheses)
CI, confidence interval
^aCumulus and Altocumulus measures fitted together
^bCumulus and Cirrocumulus measures fitted together
^cAltocumulus and Cirrocumulus measures fitted together
^dCumulus, Altocumulus and Cirrocumulus measures fitted together

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ISSN: 1465-542X

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