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Table 2 Change in self-reported neurotoxicity scores (FACT/GOG-Ntx subscale) pre to post chemotherapy treatment by population characteristics (n = 900)

From: Associations between self-reported diet during treatment and chemotherapy-induced peripheral neuropathy in a cooperative group trial (S0221)

  Total < 10%a 10–30%a > 30%a p valueb
Characteristic (mean ± SD)   281 (31.2) 306 (34.0) 313 (34.8)  
Age at baseline (years) (52.0 ± 9.7)c      0.003
  < 40 93 (10.3) 33 (11.7) 43 (14.1) 17 (5.4)  
 40–49 275 (30.6) 97 (34.5) 87 (28.5) 91 (29.1)  
 50–59 323 (35.9) 92 (32.7) 109 (35.7) 122 (39.0)  
  ≥ 60 208 (23.1) 59 (21.0) 66 (21.6) 83 (26.5)  
Race/ethnicity      0.98
 Non-Hispanic White 762 (84.7) 238 (84.7) 259 (84.6) 265 (84.7)  
 Spanish/Latino/Hispanic 27 (3.0) 7 (2.5) 9 (2.9) 11 (3.5)  
 Black/African American 56 (6.2) 19 (6.8) 20 (6.5) 17 (5.4)  
 Other 55 (6.1) 17 (6.1) 18 (5.9) 20 (6.4)  
BMI at baseline (kg/m2)c (28.7 ± 6.5)      0.03
 Underweight (< 18.5) 8 (0.9) 6 (2.2) 1 (0.3) 1 (0.3)  
 Normal/underweight (18.5–24.9) 278 (31.3) 103 (37.1) 103 (34.1) 72 (23.3)  
 Overweight (25.0–29.9) 287 (32.3) 84 (30.22) 85 (28.2) 118 (38.2)  
 Obese (30.0+) 316 (35.6) 85 (30.6) 113 (37.4) 118 (38.2)  
BMI at follow-up (kg/m2)c (28.5 ± 6.4)      0.16
 Underweight (< 18.5) 8 (0.9) 4 (1.4) 2 (0.7) 2 (0.7)  
 Normal (18.5–24.9) 281 (31.7) 103 (37.2) 99 (33.0) 79 (25.6)  
 Overweight (25.0–29.9) 304 (34.3) 93 (33.6) 88 (29.3) 123 (39.8)  
 Obese (30.0+) 293 (33.1) 77 (27.8) 111 (37.0) 105 (34.0)  
Change in weight during treatment      0.007
 Lost weight 56 (6.2) 8 (2.9) 15 (4.9) 33 (10.5)  
 Did not change 772 (85.8) 256 (91.1) 263 (86.0) 253 (80.8)  
 Gained weight 72 (8.0) 17 (6.1) 28 (9.2) 27 (8.6)  
Menopausal status      0.009
 Pre 407 (45.2) 135 (48.0) 152 (49.7) 120 (38.3)  
 Post 493 (54.8) 146 (52.0) 154 (50.3) 193 (61.7)  
Smoking status      0.09
 Never 511 (57.0) 169 (60.4) 182 (59.7) 160 (51.3)  
 Former 285 (31.8) 84 (30.0) 94 (30.8) 107 (34.3)  
 Current 101 (11.3) 27 (9.6) 29 (9.5) 45 (14.4)  
Highest education      0.21
 Did not complete high school 51 (5.7) 22 (7.9) 11 (3.6) 18 (5.8)  
 High school 188 (21.0) 54 (19.4) 63 (20.7) 71 (22.7)  
 Some college or technical school 325 (36.3) 97 (34.8) 105 (34.5) 123 (39.3)  
 College graduate 196 (21.9) 64 (22.9) 70 (23.0) 62 (19.8)  
 Advanced degree 136 (15.2) 42 (15.1) 55 (18.1) 39 (12.5)  
Marital status      0.80
 Married/living as married 682 (76.2) 216 (77.1) 232 (76.6) 234 (75.0)  
 Widowed 38 (4.3) 15 (5.4) 9 (3.0) 14 (4.5)  
 Divorced/separated 127 (14.2) 35 (12.5) 45 (14.9) 47 (15.1)  
 Single/never married 48 (5.4) 14 (5.0) 17 (5.6) 17 (5.5)  
  1. Data presented as N (%)
  2. SD standard deviation, FACT/GOG-Ntx Functional Assessment of Cancer Treatment Gynecologic Oncology Group—Neurotoxicity
  3. aPercent increase in neuropathy severity (based on self-reported score)
  4. bChi-square test for independence, analysis of variance for continuous variables (α = 0.05)
  5. cModeled as continuous variable