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Table 5 Multivariable Cox regression analysis of tamoxifen-treated postmenopausal women on the overall survival (OS) and disease-free survival (DFS) including HER4, patient age, and tumor stage

From: HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women

 

OS (n = 64, events = 12)

DFS (n = 64, events = 12)

HR

95% CI

p value

HR

95% CI

p value

Model 1

 HER4 continuous

1.41

1.02

1.95

0.035

2.34

1.34

4.06

0.003

 Age

1.14

1.07

1.21

< 0.001

1.11

1.05

1.18

< 0.001

 pT stage (ref. pT1)

4.98

1.11

22.37

0.036

4.01

1.10

14.64

0.035

Model 2

 HER4 ≥ 1 (ref. HER4 < 1)

3.89

0.92

16.37

0.064

2.38

0.71

8.00

0.161

 Age

1.12

1.05

1.18

< 0.001

1.09

1.04

1.15

0.001

 pT2 or higher (ref. pT1)

6.68

1.60

27.93

0.009

3.80

1.13

12.80

0.031

  1. Significant values that refer to HER4 are shown in bold typeface
  2. CI confidence interval, HR hazard ratio, pT tumor stage
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Breast Cancer Research

ISSN: 1465-542X

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