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Table 5 Multivariable Cox regression analysis of tamoxifen-treated postmenopausal women on the overall survival (OS) and disease-free survival (DFS) including HER4, patient age, and tumor stage

From: HER4 expression in estrogen receptor-positive breast cancer is associated with decreased sensitivity to tamoxifen treatment and reduced overall survival of postmenopausal women

  OS (n = 64, events = 12) DFS (n = 64, events = 12)
HR 95% CI p value HR 95% CI p value
Model 1
 HER4 continuous 1.41 1.02 1.95 0.035 2.34 1.34 4.06 0.003
 Age 1.14 1.07 1.21 < 0.001 1.11 1.05 1.18 < 0.001
 pT stage (ref. pT1) 4.98 1.11 22.37 0.036 4.01 1.10 14.64 0.035
Model 2
 HER4 ≥ 1 (ref. HER4 < 1) 3.89 0.92 16.37 0.064 2.38 0.71 8.00 0.161
 Age 1.12 1.05 1.18 < 0.001 1.09 1.04 1.15 0.001
 pT2 or higher (ref. pT1) 6.68 1.60 27.93 0.009 3.80 1.13 12.80 0.031
  1. Significant values that refer to HER4 are shown in bold typeface
  2. CI confidence interval, HR hazard ratio, pT tumor stage