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Table 4 Risk of incident osteopenia and osteoporosis among recent breast cancer survivors compared with cancer-free women, stratified by follow-up timea

From: Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study

  Events/person-years Age-adjusted HR (95% CI) MV-adjusted HR (95% CI)b
Overall
 Cancer-free 67/3497 1.00 (reference) 1.00 (reference)
 Survivors 27/475 2.49 (1.58–3.91) 2.17 (1.37–3.46)
0–2 years
 Cancer-free 22/1126 1.00 (reference) 1.00 (reference)
 Survivors 14/214 3.15 (1.61–6.17) 2.74 (1.37–5.47)
3+ years    
 Cancer-free 45/2371 1.00 (reference) 1.00 (reference)
 Survivors 13/261 2.07 (1.11–3.85) 1.85 (0.98–3.51)
  1. Abbreviations: MV Multivariable
  2. aBreast cancer survivors were restricted to women diagnosed within 1 year prior to enrollment
  3. bAdjusted for age (years), menopausal status (premenopausal, postmenopausal), bilateral oophorectomy at age < 45 years (yes, no), body mass index (kg/m2), physical activity (MET-h/wk), smoking status (never, ever), alcohol intake (g/d), and hormone replacement therapy (never, ever)
  4. p(s) for the likelihood ratio test of the interaction between breast cancer status and time was 0.42 for age- and 0.44 for MV-adjusted models
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