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Table 4 Risk of incident osteopenia and osteoporosis among recent breast cancer survivors compared with cancer-free women, stratified by follow-up timea

From: Evaluation of osteopenia and osteoporosis in younger breast cancer survivors compared with cancer-free women: a prospective cohort study

 

Events/person-years

Age-adjusted HR (95% CI)

MV-adjusted HR (95% CI)b

Overall

 Cancer-free

67/3497

1.00 (reference)

1.00 (reference)

 Survivors

27/475

2.49 (1.58–3.91)

2.17 (1.37–3.46)

0–2 years

 Cancer-free

22/1126

1.00 (reference)

1.00 (reference)

 Survivors

14/214

3.15 (1.61–6.17)

2.74 (1.37–5.47)

3+ years

   

 Cancer-free

45/2371

1.00 (reference)

1.00 (reference)

 Survivors

13/261

2.07 (1.11–3.85)

1.85 (0.98–3.51)

  1. Abbreviations: MV Multivariable
  2. aBreast cancer survivors were restricted to women diagnosed within 1 year prior to enrollment
  3. bAdjusted for age (years), menopausal status (premenopausal, postmenopausal), bilateral oophorectomy at age < 45 years (yes, no), body mass index (kg/m2), physical activity (MET-h/wk), smoking status (never, ever), alcohol intake (g/d), and hormone replacement therapy (never, ever)
  4. p(s) for the likelihood ratio test of the interaction between breast cancer status and time was 0.42 for age- and 0.44 for MV-adjusted models