Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in breast cancer progression

Table 2 Univariate and multivariate Cox analysis of survival

Parameter	Overall survival
	Univariate Cox analysis			Multivariate Cox analysis
	HR	95% CI	p value	HR	95% CI	p value
Age
≤ 50 years	4.172	1.673–10.402	0.002	3.767	1.500–9.461	0.005
> 50 years
Tumour grade
G1	1.235	0.887–1.719	0.212
G2
G3
Tumour size
pT1	1.028	1.010–1.045	0.002	2.012	1.469–2.754	< 0.0001
pT2
pT3
pT4
Lymph nodes
pN0	1.921	1.010–1.045	0.038	2.294	1.295–4.065	0.004
pN1–pN3
pNx
pM
M0	11.48	1.399–90.427	0.023	7.378	0.936–58.136	0.058
M1
Stage
I	1.025	1.006–1.045	0.010	0.512	0.374–0.701	< 0.0001
II
III
IV
Oestrogen receptor
Negative	1.009	0.999–1.019	0.078
Positive
Progesterone receptor
Negative	0.991	0.972–1.010	0.355
Positive
HER2
Negative	1.002	0.983–1.021	0.847
Positive
Molecular tumour types
Triple negative	1.400	0.612–3.200	0.425
Other types	1.400	0.612–3.200	0.425
GAL3ST1
Negative (0)	0.595	0.354–0.999	0.046	0.604	0.351–1.038	0.068
Positive (1–12)	0.595	0.354–0.999	0.046	0.604	0.351–1.038	0.068
GAL3ST1 chemotherapy subgroup
Negative (0)	0.659	0.388–1118	0.112
Positive (1–12)	0.659	0.388–1118	0.112

Bold values (p < 0.05) are statistically significant
CI confidence interval, Gal3ST1 galactosylceramide sulfotransferase, HR hazard ratio, HER2 human epidermal growth factor receptor 2

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