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Table 2 Univariate and multivariate Cox analysis of survival

From: Sulfatide decreases the resistance to stress-induced apoptosis and increases P-selectin-mediated adhesion: a two-edged sword in breast cancer progression

Parameter Overall survival
Univariate Cox analysis Multivariate Cox analysis
HR 95% CI p value HR 95% CI p value
Age
 ≤ 50 years 4.172 1.673–10.402 0.002 3.767 1.500–9.461 0.005
 > 50 years       
Tumour grade
 G1 1.235 0.887–1.719 0.212    
 G2       
 G3       
Tumour size
 pT1 1.028 1.010–1.045 0.002 2.012 1.469–2.754 < 0.0001
 pT2       
 pT3       
 pT4       
Lymph nodes
 pN0 1.921 1.010–1.045 0.038 2.294 1.295–4.065 0.004
 pN1–pN3       
 pNx       
pM
 M0 11.48 1.399–90.427 0.023 7.378 0.936–58.136 0.058
 M1       
Stage
 I 1.025 1.006–1.045 0.010 0.512 0.374–0.701 < 0.0001
 II       
 III       
 IV       
Oestrogen receptor
 Negative 1.009 0.999–1.019 0.078    
 Positive       
Progesterone receptor
 Negative 0.991 0.972–1.010 0.355    
 Positive       
HER2
 Negative 1.002 0.983–1.021 0.847    
 Positive       
Molecular tumour types
 Triple negative 1.400 0.612–3.200 0.425    
 Other types
GAL3ST1
 Negative (0) 0.595 0.354–0.999 0.046 0.604 0.351–1.038 0.068
 Positive (1–12)
GAL3ST1 chemotherapy subgroup
 Negative (0) 0.659 0.388–1118 0.112    
 Positive (1–12)
  1. Bold values (p < 0.05) are statistically significant
  2. CI confidence interval, Gal3ST1 galactosylceramide sulfotransferase, HR hazard ratio, HER2 human epidermal growth factor receptor 2