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Fig. 1 | Breast Cancer Research

Fig. 1

From: Loss of amphiregulin reduces myoepithelial cell coverage of mammary ducts and alters breast tumor growth

Fig. 1

In absence of AREG, growth of lesions accelerated. a–d Representative images of carmine-stained AREG+/+ PyMT and AREG−/− PyMT mammary fat pads at 6 weeks and 12 weeks. Lesions marked by arrows. Scale bar shows 2000 μm. e Total lesion area measured for AREG+/+ PyMT (black bars) and AREG−/− PyMT (gray bars) mice, respectively. At least seven animals measured for 6-week group and at least three animals for 12-week group. f, g AREG−/− PyMT palpable lesions reached 1-cm diameter more rapidly. f Kaplan–Meier plot of percentage of mice with palpable lesions less than 1 cm for AREG−/− PyMT mice (dotted line, N = 33) and AREG+/+ PyMT mice (solid line, N = 50). g Mean and SEM of data in (f). Statistical analysis performed using a log-rank test (f) and t test (e, g). *p < 0.05, **p < 0.01. AREG amphiregulin, PYMT polyoma middle-T antigen

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