BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

Sethuraman, Aarti; Brown, Martin; Krutilina, Raya; Wu, Zhao-Hui; Seagroves, Tiffany N.; Pfeffer, Lawrence M.; Fan, Meiyun

doi:10.1186/s13058-018-1046-3

Breast Cancer Research

Table 1 Correlated expression of BHLHE40 and its putative targets in breast tumors (The Cancer Genome Atlas)

From: BHLHE40 confers a pro-survival and pro-metastatic phenotype to breast cancer cells by modulating HBEGF secretion

Gene	BL (n = 230)		Her2 (n = 162)		LA (n = 315)		LB (n = 300)
Gene	Pearson r	p value	Pearson r	p value	Pearson r	p value	Pearson r	p value
CCL3L1	0.1210	0.0694	−0.2045	0.0095	0.0504	0.3792	0.0480	0.4136
CMTM3	−0.0042	0.9494	0.0358	0.6510	0.5065	< 0.0001	−0.0521	0.3687
CMTM7	−0.2761	< 0.0001	−0.0697	0.3780	0.2516	< 0.0001	0.0635	0.2729
CMTM8	−0.1580	0.0165	−0.0886	0.2624	0.1034	0.0670	−0.0013	0.9817
CSPG5	−0.1333	0.0435	−0.0309	0.6961	−0.0351	0.5345	−0.0504	0.3850
CTGF	0.0203	0.7593	0.3087	< 0.0001	0.4876	< 0.0001	0.0631	0.2760
EBI3	0.2135	0.0011	−0.2060	0.0085	0.0805	0.1543	−0.0271	0.6402
EDN1	0.0705	0.2867	0.0928	0.2401	0.3805	< 0.0001	0.0273	0.6379
FGF1	0.1666	0.0114	0.2470	0.0015	0.4225	< 0.0001	0.0357	0.5384
FGF13	−0.1105	0.0946	−0.1782	0.0233	0.1393	0.0134	−0.1276	0.0271
FLT3LG	0.2436	0.0002	−0.0588	0.4573	0.2878	< 0.0001	−0.0264	0.6487
GMFG	0.2593	< 0.0001	−0.1764	0.0247	0.3367	< 0.0001	−0.1271	0.0277
HBEGF	0.3871	< 0.0001	0.2873	0.0002	0.3254	< 0.0001	0.1577	0.0062
IL11	0.1413	0.0322	0.1762	0.0249	0.2053	0.0002	0.0328	0.5710
IL12A	0.0325	0.6207	−0.0582	0.4618	−0.1035	0.0649	−0.1543	0.0069
IL15	0.3407	< 0.0001	0.0628	0.4273	0.1632	0.0037	−0.0913	0.1146
IL17A	0.1036	0.1139	0.0845	0.2850	−0.0221	0.6942	−0.0919	0.1094
IL1A	0.2140	0.0013	−0.0057	0.9440	0.0399	0.4960	−0.0720	0.2359
IL25	−0.1011	0.3633	0.0560	0.6578	−0.1569	0.0293	0.1617	0.0661
IL32	0.1597	0.0153	−0.0571	0.4704	0.3242	< 0.0001	−0.0473	0.4141
JAG2	−0.0418	0.5287	0.0387	0.6250	0.0880	0.1190	−0.0167	0.7729
MDK	−0.0837	0.2057	−0.0947	0.2305	0.1107	0.0496	0.0066	0.9099
NAMPT	0.2678	< 0.0001	0.0873	0.2691	0.1667	0.0030	−0.1819	0.0016
NRTN	−0.4457	< 0.0001	−0.0350	0.6596	0.0672	0.2411	−0.0288	0.6220
TFF1	0.2156	0.0009	−0.0148	0.8516	0.0221	0.6936	−0.1243	0.0300
TNFSF12	0.1690	0.0102	−0.0271	0.7323	0.1482	0.0084	0.0565	0.3296
VEGFB	−0.0460	0.4879	0.0811	0.3049	0.2028	0.0003	0.0443	0.4449
VEGFC	0.3664	< 0.0001	0.1760	0.0251	1.0000	< 0.0001	−0.0922	0.1110

The correlation analysis was performed using the mRNA expression z scores (RNA Seq V2 RSEM, The Cancer Genome Atlas)
BL basal-like, Her2 ERBB2-enriched, LA luminal A, LB luminal B

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