Skip to main content
Fig. 1 | Breast Cancer Research

Fig. 1

From: Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro

Fig. 1

Metadherin (MTDH) overexpression affects the prognosis of breast cancer patients who were treated with neoadjuvant chemotherapy. a Immunohistochemical staining with MTDH expression in breast cancer tissues (200×). Abbreviations: HE histopathology, IHC immunohistochemistry. b After neoadjuvant chemotherapy, in the MTDH low group (n = 15), 4 cases achieved complete response (CR), 9 cases achieved partial response (PR), 2 cases achieved stable disease (SD), and 0 case achieved progression disease (PD). In the high MTDH expression group (n = 29), 3 cases achieved CR, 16 cases achieved PR, 7 cases achieved SD, and 3 cases achieved PD. After surgery, the percentages of pathologic complete response (pCR) were 33.3% in the low MTDH expression group and 17.2% in the high MTDH expression group. c and d Patients with high MTDH expression had worse disease-free survival (P = 0.018) and overall survival (P = 0.004) than those with low MTDH expression

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us